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通过精子传递跨代表观遗传信息：精子不仅为新生命提供了一半的基因组；它们似乎还通过表观遗传修饰传递额外的信息。

Transgenerational epigenetic information through the sperm: Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications.

机构信息

Department of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

EMBO Rep. 2021 Aug 4;22(8):e53539. doi: 10.15252/embr.202153539. Epub 2021 Jul 20.

DOI:10.15252/embr.202153539
PMID:34288347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8344929/
Abstract

The biological cause for the increase in Autism Spectrum Disorder may be fathers' older age and the epigenetic marks it leaves on sperm cells.

摘要

自闭症谱系障碍增加的生物学原因可能是父亲年龄较大以及它在精子细胞上留下的表观遗传标记。

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1
Transgenerational epigenetic information through the sperm: Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications.通过精子传递跨代表观遗传信息：精子不仅为新生命提供了一半的基因组；它们似乎还通过表观遗传修饰传递额外的信息。
EMBO Rep. 2021 Aug 4;22(8):e53539. doi: 10.15252/embr.202153539. Epub 2021 Jul 20.
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Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites.表观遗传跨代传递改变的精子组蛋白保留位点。
Sci Rep. 2018 Mar 28;8(1):5308. doi: 10.1038/s41598-018-23612-y.
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Epigenetic Transgenerational Inheritance.表观遗传跨代遗传。
Adv Exp Med Biol. 2019;1166:57-74. doi: 10.1007/978-3-030-21664-1_4.
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Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort.在一个自闭症高发队列中，父系精子DNA甲基化与自闭症风险的早期迹象相关。
Int J Epidemiol. 2015 Aug;44(4):1199-210. doi: 10.1093/ije/dyv028. Epub 2015 Apr 14.
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Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health.跨代遗传：父母的表观遗传和遗传信息如何影响后代的健康。
Hum Reprod Update. 2019 Sep 11;25(5):518-540. doi: 10.1093/humupd/dmz017.
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Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.父代环境暴露对子代大脑功能和精神疾病易感性的跨代表观遗传影响。
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Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome.遗传和表观遗传变异而非饮食塑造精子甲基化组。
Dev Cell. 2015 Dec 21;35(6):750-8. doi: 10.1016/j.devcel.2015.11.024.
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Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations.环境诱导的精子表观突变的表观遗传跨代遗传促进基因突变。
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Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm.父系衰老导致神经发育性疾病的风险：精子中表观遗传改变的可能影响。
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[Epigenetics' implication in autism spectrum disorders: A review].[表观遗传学在自闭症谱系障碍中的影响：综述]
Encephale. 2017 Aug;43(4):374-381. doi: 10.1016/j.encep.2016.07.007. Epub 2016 Sep 28.

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Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice.父亲年龄较大使新生小鼠发声模式的个体轨迹多样化。
iScience. 2022 Aug 11;25(8):104834. doi: 10.1016/j.isci.2022.104834. eCollection 2022 Aug 19.
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Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder.接触高水平的持久性内分泌干扰化合物会影响与自闭症谱系障碍相关区域的精子甲基化组。
Front Genet. 2022 Aug 11;13:929471. doi: 10.3389/fgene.2022.929471. eCollection 2022.

本文引用的文献

1
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.父亲年龄通过涉及 REST/NRSF 的表观遗传机制影响后代。
EMBO Rep. 2021 Feb 3;22(2):e51524. doi: 10.15252/embr.202051524. Epub 2021 Jan 5.
2
Autism risk in offspring can be assessed through quantification of male sperm mosaicism.自闭症风险可通过量化男性精子嵌合性进行评估。
Nat Med. 2020 Jan;26(1):143-150. doi: 10.1038/s41591-019-0711-0. Epub 2019 Dec 23.
3
Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.父代环境暴露对子代大脑功能和精神疾病易感性的跨代表观遗传影响。
Mol Psychiatry. 2019 Apr;24(4):536-548. doi: 10.1038/s41380-018-0039-z. Epub 2018 Mar 8.
4
Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring.母亲在怀孕前和怀孕期间使用叶酸和多种维生素补充剂与后代自闭症谱系障碍风险的关联。
JAMA Psychiatry. 2018 Feb 1;75(2):176-184. doi: 10.1001/jamapsychiatry.2017.4050.
5
Maternal Multivitamin Intake, Plasma Folate and Vitamin B Levels and Autism Spectrum Disorder Risk in Offspring.孕期多种维生素摄入、母体血浆叶酸和维生素B水平与子代患自闭症谱系障碍的风险
Paediatr Perinat Epidemiol. 2018 Jan;32(1):100-111. doi: 10.1111/ppe.12414. Epub 2017 Oct 6.
6
Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes.小鼠精子中的染色质状态与胚胎和成体调控格局相关。
Cell Rep. 2017 Feb 7;18(6):1366-1382. doi: 10.1016/j.celrep.2017.01.034.
7
Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations.高龄父亲导致精神疾病的风险并非主要来自新生突变。
Nat Genet. 2016 Jul;48(7):718-24. doi: 10.1038/ng.3577. Epub 2016 May 23.
8
Autism risk associated with parental age and with increasing difference in age between the parents.自闭症风险与父母年龄以及父母之间年龄差距的增大有关。
Mol Psychiatry. 2016 May;21(5):693-700. doi: 10.1038/mp.2015.70. Epub 2015 Jun 9.
9
Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort.在一个自闭症高发队列中，父系精子DNA甲基化与自闭症风险的早期迹象相关。
Int J Epidemiol. 2015 Aug;44(4):1199-210. doi: 10.1093/ije/dyv028. Epub 2015 Apr 14.
10
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.小头畸形基因将 trithorax 和 REST/NRSF 联系起来，以控制神经干细胞的增殖和分化。
Cell. 2012 Nov 21;151(5):1097-112. doi: 10.1016/j.cell.2012.10.043.