Department of Biology, Northeastern University, Boston, MA, USA.
EMBO Rep. 2021 Aug 4;22(8):e53265. doi: 10.15252/embr.202153265. Epub 2021 Jul 20.
Cells release extracellular vesicles to remove damaged components and communicate with other cells via packets of proteins, lipids, and RNAs. Neuronal cells in the nematode C. elegans release particularly large extracellular vesicles, known as exophers, to rid themselves of damaged organelles and protein aggregates. Turek et al now demonstrate a new role for these vesicles: Embryos in the uterus stimulate body wall muscle cells to release exophers laden with yolk, which are taken up by oocytes to nourish the next set of embryos (Turek et al, 2021).
细胞通过蛋白质、脂质和 RNA 等包裹体释放细胞外囊泡，以清除受损成分并与其他细胞进行通讯。秀丽隐杆线虫中的神经元细胞会释放特别大的细胞外囊泡，称为外泌体，以清除受损的细胞器和蛋白质聚集体。现在，图雷克等人证明了这些囊泡的一个新作用：子宫中的胚胎刺激体壁肌肉细胞释放富含卵黄的外泌体，这些外泌体被卵母细胞吸收，以滋养下一组胚胎（Turek 等人，2021 年）。
