Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, Iowa, USA.
Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa, USA.
J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):422-430. doi: 10.1002/jbm.b.34918. Epub 2021 Jul 21.
Fast acting topical hemostatic agents play a key role in hemorrhage control. Retarding fibrinolysis is also critical in improving coagulation, thereby expanding chances of survival. The purpose of the present work was to investigate the physical properties, loading capacity and hemostatic efficacy of newly developed nanoclay microsphere frameworks (NMFs) loaded with tranexamic acid (TA), as antifibrinolytic agent. Nanoclay compositions were prepared with increasing levels of TA. Results showed that TA was successfully incorporated into the nanoclay structure and released when solvated with ethanol. Both doped and undoped NMFs significantly decreased activated partial thromboplastin time and increased clot stiffness, which was attributed to significantly thinner fibrin fibers and a denser clot structure.
速效局部止血剂在控制出血方面起着关键作用。延缓纤维蛋白溶解对于改善凝血也至关重要，从而提高了生存机会。本工作的目的是研究载有氨甲环酸（TA）的新型纳米粘土微球框架（NMF）的物理性质、载药量和止血效果，作为抗纤维蛋白溶解剂。用越来越多的 TA 制备纳米粘土组合物。结果表明，TA 成功地掺入纳米粘土结构中，并在与乙醇溶剂化时释放。掺杂和未掺杂的 NMF 均显著降低了活化部分凝血活酶时间，并增加了血栓硬度，这归因于更细的纤维蛋白纤维和更致密的血栓结构。
