Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
FEBS J. 2021 Nov;288(21):6187-6205. doi: 10.1111/febs.16133. Epub 2021 Jul 28.
The old Greek aphorism 'Panta Rhei' ('everything flows') is true for all living things in general. As a dynamic process, calcium signaling plays fundamental roles in cellular activities under both normal and pathological conditions, with recent researches uncovering its involvement in cell proliferation, migration, survival, gene expression, and more. The major question we address here is how calcium signaling affects cancer progression and whether it could be targeted to combine with classic chemotherapeutics or emerging immunotherapies to improve their efficacy.
古希腊格言“一切皆变”（“Panta Rhei”）对所有生物都是适用的。作为一个动态的过程，钙信号在正常和病理条件下的细胞活动中发挥着基础性作用，最近的研究揭示了其在细胞增殖、迁移、存活、基因表达等方面的作用。我们在这里主要关注的问题是钙信号如何影响癌症的进展，以及是否可以靶向钙信号来结合经典的化疗药物或新兴的免疫疗法以提高它们的疗效。
