Hagel H J, Melchner M, Kachel G, Ruppin H, Croft D N, Domschke W
Department of Medicine, University of Erlangen-Nuremberg, FRG.
Hepatogastroenterology. 1987 Dec;34(6):262-4.
Gastric epithelial cell loss was studied in healthy volunteers before and after intragastric instillation of four aspirin (ASA) formulations and three strengths of alcohol. Each test solution was administered three times over a period of three hours during one of the experiments. Three of the four aspirin formulations significantly increased gastric epithelial cell loss. Microencapsulated aspirin increased gastric epithelial cell loss significantly, but only after the third dose. Alcohol, 10% (wine), increased cell loss to a similar extent as did microencapsulated aspirin. Alcohol, 20% (campari), and 40% (whisky), significantly enhanced cell loss to such a degree as was elicited by the two strengths of soluble aspirin. Thus, gastric cell loss increased dose-dependently after both aspirin and alcohol. The data suggest that, in man, gastric epithelial cell damage caused by different aspirin formulations and alcohol concentrations is reproducible and dose-dependent.
在健康志愿者中，研究了胃内滴注四种阿司匹林（ASA）制剂和三种浓度酒精前后的胃上皮细胞损失情况。在其中一项实验中，每种测试溶液在三小时内分三次给药。四种阿司匹林制剂中的三种显著增加了胃上皮细胞损失。微囊化阿司匹林显著增加了胃上皮细胞损失，但仅在第三次给药后。10%（葡萄酒）的酒精增加细胞损失的程度与微囊化阿司匹林相似。20%（金巴利酒）和40%（威士忌）的酒精显著增强细胞损失，其程度与两种浓度的可溶性阿司匹林引起的程度相同。因此，阿司匹林和酒精后胃细胞损失均呈剂量依赖性增加。数据表明，在人类中，不同阿司匹林制剂和酒精浓度引起的胃上皮细胞损伤是可重复的且呈剂量依赖性。
