Lanza F L, Royer G L, Nelson R S, Rack M F, Seckman C C
Am J Gastroenterol. 1985 Oct;80(10):767-9.
The effect on the gastroduodenal mucosa of alcohol combined either with aspirin or ibuprofen was studied in 60 normal volunteers. The volunteers were divided into six groups comprised of 10 subjects receiving ibuprofen, placebo, or aspirin with or without alcohol. Medications consisted of 1) three 325-mg aspirin tablets, or three identical placebo tablets, 2) one 600-mg ibuprofen tablet, and 3), three ounces of 100 proof vodka diluted in 6 ounces of orange juice, or alcohol placebo made by diluting 3 ounces of water in orange juice. All subjects received 4 doses over a 24-hr period and underwent endoscopic examination the following morning. The gastroduodenal mucosa was graded according to a 0 to 4 + scale. Aspirin caused considerably greater duodenal and gastric damage than did either ibuprofen or placebo. The addition of alcohol to all drugs increased the damage seen in the stomach but not to a significant degree; this effect was slightly more pronounced with ibuprofen than with placebo or aspirin and approached significance (0.1 greater than p greater than 0.05). These results are compatible with alcohol being a mild damaging agent or a potentiating agent for damage from other drugs.
在60名正常志愿者中研究了酒精与阿司匹林或布洛芬联合使用对胃十二指肠黏膜的影响。志愿者被分为六组，每组10人，分别接受布洛芬、安慰剂、阿司匹林，以及是否搭配酒精。药物包括：1）三片325毫克的阿司匹林片，或三片相同的安慰剂片；2）一片600毫克的布洛芬片；3）三盎司100度的伏特加稀释在6盎司橙汁中，或由3盎司水稀释在橙汁中制成的酒精安慰剂。所有受试者在24小时内接受4剂药物，并在次日早晨接受内镜检查。胃十二指肠黏膜根据0至4+的等级进行评分。阿司匹林造成的十二指肠和胃部损伤比布洛芬或安慰剂严重得多。所有药物中添加酒精会增加胃部的损伤，但程度不显著；布洛芬的这种作用比安慰剂或阿司匹林略明显，且接近显著水平（0.1＞p＞0.05）。这些结果表明酒精可能是一种轻度损伤剂，或者是增强其他药物损伤作用的增效剂。
