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雄激素对大鼠腹侧前列腺中乙酸盐掺入膜脂的调控

Androgenic control of acetate incorporation into membrane lipids in rat ventral prostate.

作者信息

Recio M N, del Hoyo N, Pérez-Albarsanz M A

机构信息

Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.

出版信息

Biochem Int. 1988 Jan;16(1):1-13.

PMID:3355567
Abstract

The rat ventral prostate plasma membranes incorporated acetate into total lipids, which was a time-dependent process. The acetate incorporation was mainly into phospholipids followed by cholesterol. The main phospholipids subclasses were choline and ethanolamine glycerophospholipids. Castration modified drastically both cholesterol-phospholipids and choline glycerophospholipids-ethanolamine glycerophospholipids ratios. These effects of castration were reversed after testosterone treatment, which could suggest an influence of this hormone in the modification of some lipid classes into cellular membrane.

摘要

大鼠腹侧前列腺质膜将乙酸盐掺入总脂质中,这是一个时间依赖性过程。乙酸盐掺入主要进入磷脂,其次是胆固醇。主要的磷脂亚类是胆碱和乙醇胺甘油磷脂。去势极大地改变了胆固醇-磷脂以及胆碱甘油磷脂-乙醇胺甘油磷脂的比例。睾酮治疗后,去势的这些影响得到逆转,这可能表明该激素对细胞膜中某些脂质类别的修饰有影响。

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