Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB0630K, Boston, MA, 02115, USA.
Sci Rep. 2021 Jul 21;11(1):14848. doi: 10.1038/s41598-021-93966-3.
Cardiovascular disease risk factor profiles and health behaviors are known to differ between women and men. Sex-based differences in ideal cardiovascular health were examined in the My Research Legacy study, which collected cardiovascular health and lifestyle data via Life's Simple 7 survey and digital health devices. As the study overenrolled women (n = 1251) compared to men (n = 310), we hypothesized that heterogeneity among women would affect comparisons of ideal cardiovascular health. We identified 2 phenogroups of women in our study cohort by cluster analysis. The phenogroups differed significantly across all 7 cardiovascular health and behavior domains (all p < 0.01) with women in phenogroup 1 having a lower Life's Simple 7 Health Score than those in phenogroup 2 (5.9 ± 1.3 vs. 7.6 ± 1.3, p < 0.01). Compared to men, women in phenogroup 1 had a higher burden of cardiovascular disease risk factors, exercised less, and had lower ideal cardiovascular health scores (p < 0.01). In contrast, women in phenogroup 2 had fewer cardiovascular risk factors but similar exercise habits and higher ideal cardiovascular health scores than men (p < 0.01). These findings suggest that heterogeneity among study participants should be examined when evaluating sex-based differences in ideal cardiovascular health.
心血管疾病风险因素谱和健康行为在女性和男性之间存在差异。本研究通过“生活简单 7”调查和数字健康设备收集心血管健康和生活方式数据，探讨了基于性别的理想心血管健康差异。由于该研究女性参与者(n=1251)多于男性(n=310)，我们假设女性的异质性会影响理想心血管健康的比较。我们通过聚类分析确定了研究队列中的 2 种女性表型组。这两个表型组在所有 7 个心血管健康和行为领域存在显著差异(均 p<0.01)，表型组 1 的女性的“生活简单 7”健康评分低于表型组 2 的女性(5.9±1.3 对 7.6±1.3，p<0.01)。与男性相比，表型组 1 的女性心血管疾病风险因素负担更高，运动较少，理想心血管健康评分更低(p<0.01)。相比之下，表型组 2 的女性心血管风险因素较少，但运动习惯与男性相似，理想心血管健康评分较高(p<0.01)。这些发现表明，在评估基于性别的理想心血管健康差异时，应检查研究参与者的异质性。
