Department of Thyroid Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
West China School of Nursing, Sichuan University/Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2021 Jul 5;12:595571. doi: 10.3389/fendo.2021.595571. eCollection 2021.
To investigate the effectiveness of high-concentration oxygen on the improvement of throat symptoms and voice changes after thyroid surgery and its protection of the parathyroid function.
A total of 600 patients undergoing thyroid surgery who met the inclusion criteria were randomly divided into the experimental group (n = 300) and the control group (n = 300) by using a random number generator. The patients in the experimental group underwent high-oxygen treatment [FiO80 (8 L/min)] for 6 continuous hours after returning to the ward after surgery. The patients in the control group underwent low-oxygen treatment [FiO30 (2 L/min)] for 6 continuous hours after returning to the ward after surgery.
The postoperative incision pain score of patients in the experimental group was significantly better than that in the control group at 6 h (1.07 ± 0.80 1.23 ± 0.95, =0.031) and 12 h (1.08 ± 0.64 1.20 ± 0.73, =0.041). The postoperative throat pain score of the patients in the experimental group was significantly better than that of the control group at 6 h (1.40 ± 0.85 1.59 ± 0.97, =0.011) and 12 h (1.40 ± 0.85 1.59 ± 0.97, =0.019). The PONV score of the patients in the experimental group was significantly better than that of the control group at 12 h (0.09 ± 0.19 0.14 ± 0.37, =0.024). The Voice Handicap Index score of the patients in the experimental group was significantly better than that of the control group at 24 h (2.89 ± 5.92 4.10 ± 6.31, =0.017), 36 h (2.46 ± 5.06 3.43 ± 5.97, =0.035), and 48 h (2.46 ± 5.06 3.43 ± 5.97, =0.032).
High-concentration oxygen can alleviate PONV and pain after thyroid surgery, with less severe voice changes potentially. However, its effects on swallowing function, and parathyroid function need to be further verified.
ChiCTR-IOR-17012765 (China Clinical Trial Registry clinical trial registration center [http://www.chictr.org.cn/index.aspx).
探讨高浓度氧对甲状腺手术后咽喉症状和声音变化的改善作用及其对甲状旁腺功能的保护作用。
选取符合纳入标准的 600 例行甲状腺手术的患者，采用随机数字表法将其分为实验组（n=300）和对照组（n=300）。实验组患者术后返回病房后采用高浓度氧治疗[FiO80（8 L/min）]，持续 6 小时；对照组患者术后返回病房后采用低浓度氧治疗[FiO30（2 L/min）]，持续 6 小时。
实验组患者术后 6 h（1.07±0.80 比 1.23±0.95，=0.031）和 12 h（1.08±0.64 比 1.20±0.73，=0.041）的切口疼痛评分显著优于对照组，术后 6 h（1.40±0.85 比 1.59±0.97，=0.011）和 12 h（1.40±0.85 比 1.59±0.97，=0.019）的咽喉疼痛评分显著优于对照组，术后 12 h 的恶心呕吐（PONV）评分显著低于对照组（0.09±0.19 比 0.14±0.37，=0.024）。实验组患者术后 24 h（2.89±5.92 比 4.10±6.31，=0.017）、36 h（2.46±5.06 比 3.43±5.97，=0.035）和 48 h（2.46±5.06 比 3.43±5.97，=0.032）的嗓音障碍指数评分显著优于对照组。
高浓度氧可减轻甲状腺手术后的 PONV 和疼痛，嗓音变化可能较轻。但其对吞咽功能和甲状旁腺功能的影响尚需进一步验证。
ChiCTR-IOR-17012765（中国临床试验注册中心，[http://www.chictr.org.cn/index.aspx]）。
