疫苗需要性别视角吗？流感疫苗说是的！
Do Vaccines Need a Gender Perspective? Influenza Says Yes!
机构信息
Department of Microbiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
National Influenza Center of Valladolid, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
出版信息
Front Immunol. 2021 Jul 5;12:715688. doi: 10.3389/fimmu.2021.715688. eCollection 2021.
BACKGROUND
Sex differences in immune responses are well known. However, the humoral response in males and females in the case of influenza vaccination is yet to be characterized since studies have shown uneven results.
METHODS
A retrospective study was conducted in 2,243 individuals (46.9% males) divided by age (15-64 and ≥65 years old). A serological analysis was performed by hemagglutination inhibition assay (HI) just before and 28 days after annual vaccination against seasonal influenza viruses in people vaccinated during the 2006-2018 seasons. A comparison of the humoral responses against influenza A and B viruses contained in the vaccine, between male and female individuals in young adults and elderly was conducted.
RESULTS
Significative higher humoral response against classical influenza A (H1N1), A(H1N1)pdm09 subtype and B/Victoria lineage in terms of seroconversion rate were found in elderly women. No significant differences were found in the case of A(H3N2) subtype.
CONCLUSIONS
Elderly women seem to display a greater humoral response against classical A(H1N1), pandemic A(H1N1)pmd09 and B/Victoria lineage than elderly men. Sex dimorphism does not affect young adults.
背景
性别对免疫反应的影响是众所周知的。然而，由于研究结果不一致，流感疫苗接种情况下男性和女性的体液反应仍有待描述。
方法
本研究为回顾性研究，共纳入 2243 名个体（46.9%为男性），按年龄（15-64 岁和≥65 岁）分组。在 2006-2018 年季节性流感疫苗接种季节，对接受疫苗接种者在接种前和接种后 28 天进行血凝抑制测定（HI）血清学分析。比较了年轻成年人和老年人中男性和女性对疫苗中包含的甲型和乙型流感病毒的体液反应。
结果
老年女性对经典甲型流感（H1N1）、A（H1N1）pdm09 亚型和 B/Victoria 谱系的体液反应（以血清转化率衡量）明显更高。在 A（H3N2）亚型方面，未发现显著差异。
结论
与老年男性相比，老年女性对经典 A（H1N1）、大流行 A（H1N1）pdm09 和 B/Victoria 谱系似乎表现出更强的体液反应。性别二态性对年轻人没有影响。
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