老年高血压患者循环miR-26b水平与左心室肥厚及心功能的相关性
Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension.
作者信息
Fu Jian, Lin Fang, Pan Zhengxia, Wu Chun
机构信息
Jian Fu, Department of Cardiac Surgery, Children's Hospital of Chongqing Medical University, National International Science and Technology Cooperation Base for Children's Developmental Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, P.R. China.
Fang Lin, The Second Affiliated Hospital of The Army Medical University, No. 136, Zhongshan Second Road, Yuzhong District, Chongqing 400014, P.R. China.
出版信息
Pak J Med Sci. 2021 Jul-Aug;37(4):966-971. doi: 10.12669/pjms.37.4.4048.
OBJECTIVES
To study the correlations of circulating miR-26b level with left ventricular hypertrophy (LVH) and cardiac function in elderly patients with hypertension.
METHODS
A total of 132 eligible patients were divided into low and high miR-26b level groups. Their baseline clinical data and biochemical indices were compared. The correlations between miR-26b level and echocardiographic parameters were studied by Pearson's analysis. Factors affecting LVH were explored by multivariate logistic regression analysis. The role of miR-26b in diagnosing LVH was predicted by receiver operating characteristic curve.
RESULTS
The relative expression level of miR-26b was 4.56-16.93, with a median of 7.62. The two groups had similar baseline clinical data and biochemical indices (P>0.05). Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05). Circulating miR-26b level was negatively correlated with IVST, LVPWT and LVMI (P<0.0001), and positively correlated with E/A (P<0.0001). The proportion of cardiac hypofunction cases in low miR-26b level group significantly exceeded that of high miR-26b level group (P<0.05). Age and increased IVST, LVPWT and LVMI were independent risk factors for LVH (P<0.05), and elevated miR-26b level was a protective factor (P<0.05). AUC was 0.836, and the optimal cutoff value was 8.83, with high sensitivity and specificity.
CONCLUSIONS
MiR-26b level is negatively correlated with LVH and positively correlated with left ventricular diastolic function in elderly hypertensive patients. It is a protective factor for LVH complicated with diastolic dysfunction and a potential biomarker for diagnosis.
目的
研究老年高血压患者循环miR-26b水平与左心室肥厚（LVH）及心功能的相关性。
方法
将132例符合条件的患者分为miR-26b低水平组和高水平组。比较两组患者的基线临床资料及生化指标。采用Pearson分析研究miR-26b水平与超声心动图参数的相关性。通过多因素logistic回归分析探讨影响LVH的因素。用受试者工作特征曲线预测miR-26b在诊断LVH中的作用。
结果
miR-26b的相对表达水平为4.56～16.93,中位数为7.62。两组患者的基线临床资料及生化指标相似（P>0.05）。与miR-26b高水平组相比，miR-26b低水平组的室间隔厚度（IVST）、左心室后壁厚度（LVPWT）、左心室质量指数（LVMI）及LVH病例数显著增加（P<0.05），二尖瓣舒张早期与晚期充盈速度比值（E/A）降低（P<0.05）。循环miR-26b水平与IVST、LVPWT及LVMI呈负相关（P<0.0001），与E/A呈正相关（P<0.0001）。miR-26b低水平组心功能不全病例比例显著高于miR-26b高水平组（P<0.05）。年龄及IVST、LVPWT、LVMI增加是LVH的独立危险因素（P<0.05），miR-26b水平升高是保护因素（P<0.05）。曲线下面积（AUC）为0.836，最佳截断值为8.83，具有较高的敏感性和特异性。
结论
老年高血压患者miR-26b水平与LVH呈负相关，与左心室舒张功能呈正相关。它是LVH合并舒张功能障碍的保护因素及潜在的诊断生物标志物。
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