Efe Fatma Kaplan
Fatma Kaplan Efe, Department of Internal Medicine, University of Health Sciences Kecioren Research and Training Hospital, Ankara, Turkey.
Pak J Med Sci. 2021 Jul-Aug;37(4):1128-1132. doi: 10.12669/pjms.37.4.3882.
We aimed to investigate whether Monocyte-to-HDL ratio (MHR) had an association with albuminuria in patients with diabetic nephropathy (DN).
Diabetic patients, who had admitted to the outpatient clinic of general internal disease department between September 2017 - February 2018 and had their spot urinary albumin/creatinine ratio measured, were examined retrospectively. Patients were separated based on the presence of DN. Patients with DN were grouped as Stage-I, Stage-II and Stage-III chronic kidney disease (CKD). Groups were compared in terms of MHR. The presence of a correlation between MHR and albuminuria was investigated.
MHR was found to be higher in the DN (n=85) group compared to Non- DN group. (16.2±5.5 vs. 14.3±4, p=0.037) And there was no significant difference in Stage-I, Stage-II and Stage-III CKD groups in terms of MHR. (15.2± 3.4, 16.1±6.0, 17.1±6.0, p=0.485). No significant correlation was found between MHR and albuminuria in DN and non-DN groups (p=0.634, r=0.052; p=0.553, r=-0.059).
DN group had higher MHR than non-nephropathy group, whereas, there was no correlation between albuminuria and MHR.
我们旨在研究糖尿病肾病（DN）患者的单核细胞与高密度脂蛋白比值（MHR）是否与蛋白尿有关。
回顾性分析2017年9月至2018年2月期间在内科门诊就诊并检测随机尿白蛋白/肌酐比值的糖尿病患者。根据是否存在DN对患者进行分组。将DN患者分为慢性肾脏病（CKD）I期、II期和III期。比较各组的MHR。研究MHR与蛋白尿之间是否存在相关性。
发现DN组（n = 85）的MHR高于非DN组。（16.2±5.5对14.3±4，p = 0.037）并且在CKD I期、II期和III期组之间，MHR无显著差异。（15.2±3.4、16.1±6.0、17.1±6.0，p = 0.485）。在DN组和非DN组中，未发现MHR与蛋白尿之间存在显著相关性（p = 0.634，r = 0.052；p = 0.553，r = -0.059）。
DN组的MHR高于非肾病组，然而，蛋白尿与MHR之间无相关性。
