• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

口腔局部晚期鳞状细胞癌中诱导化疗后放疗与手术后继发同步放化疗的比较

Induction Chemotherapy Followed by Radiation Therapy Versus Surgery Followed by Concurrent Chemo-Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Oral Cavity.

作者信息

Hussain A Ali Shabbir, Hafeez Abdul, Javed Ayesha, Akhtar Mahwish, Mallick Muhammad Jawaid

机构信息

Oncology, Ziauddin University, Karachi, PAK.

Oncology, Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN) Hospital, Karachi, PAK.

出版信息

Cureus. 2021 Jun 17;13(6):e15723. doi: 10.7759/cureus.15723. eCollection 2021 Jun.

DOI:10.7759/cureus.15723
PMID:34290920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8287840/
Abstract

Introduction Squamous cell carcinoma of the oral cavity is one of the top 10 malignancies reported globally. Pakistan has a high incidence of oral cancers due to the prevailing poor lifestyle habits/addictions of Pakistanis, and most patients with squamous cell carcinoma present with stage III or IV locally advanced disease. Recommended guidelines indicate surgery as the mainstay of treatment followed by radiotherapy (RT). The addition of induction chemotherapy before surgery or radiation therapy might improve outcomes with increased locoregional control rates. Methods This was a retrospective cohort study comparing the outcomes between surgery followed by concurrent chemoradiotherapy (CCRT) and induction chemotherapy followed by RT. This study primarily aimed to evaluate progression-free survival (PFS) and determine the toxicity of chemotherapy. Results We found out that the mean PFS among patients undergoing surgery and CCRT and those receiving induction chemotherapy followed by RT were 6.40 (± 2.38) months and 7.6 (± 4.76) months, respectively. Conclusion Induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil followed by RT shows satisfactory results with acceptable toxicity. However, the results are not statistically significant but support the already published data on this treatment aspect of oral cavity cancers.

摘要

引言 口腔鳞状细胞癌是全球报告的十大恶性肿瘤之一。由于巴基斯坦人普遍存在不良生活习惯/成瘾问题，巴基斯坦口腔癌发病率很高，大多数口腔鳞状细胞癌患者就诊时已处于III期或IV期局部晚期疾病。推荐指南指出，手术是主要治疗手段，放疗（RT）紧随其后。在手术或放疗前加用诱导化疗可能会提高局部区域控制率，从而改善治疗效果。方法 这是一项回顾性队列研究，比较了手术联合同步放化疗（CCRT）与诱导化疗后放疗的疗效。本研究主要目的是评估无进展生存期（PFS）并确定化疗的毒性。结果 我们发现，接受手术和CCRT的患者以及接受诱导化疗后放疗的患者的平均PFS分别为6.40（±2.38）个月和7.6（±4.76）个月。结论 多西他赛、顺铂和5-氟尿嘧啶诱导化疗后放疗显示出令人满意的结果，毒性可接受。然而，结果无统计学意义，但支持已发表的关于口腔癌这一治疗方面的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/7ef05ff4c2ef/cureus-0013-00000015723-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/3258fc9ad343/cureus-0013-00000015723-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/b4fe7891bab3/cureus-0013-00000015723-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/fda2b2837d57/cureus-0013-00000015723-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/4cecbd5e9164/cureus-0013-00000015723-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/bfb71c762326/cureus-0013-00000015723-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/27f7004f9349/cureus-0013-00000015723-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/6e28338683fc/cureus-0013-00000015723-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/7ef05ff4c2ef/cureus-0013-00000015723-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/3258fc9ad343/cureus-0013-00000015723-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/b4fe7891bab3/cureus-0013-00000015723-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/fda2b2837d57/cureus-0013-00000015723-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/4cecbd5e9164/cureus-0013-00000015723-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/bfb71c762326/cureus-0013-00000015723-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/27f7004f9349/cureus-0013-00000015723-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/6e28338683fc/cureus-0013-00000015723-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a51/8287840/7ef05ff4c2ef/cureus-0013-00000015723-i08.jpg

相似文献

1
Induction Chemotherapy Followed by Radiation Therapy Versus Surgery Followed by Concurrent Chemo-Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Oral Cavity.口腔局部晚期鳞状细胞癌中诱导化疗后放疗与手术后继发同步放化疗的比较
Cureus. 2021 Jun 17;13(6):e15723. doi: 10.7759/cureus.15723. eCollection 2021 Jun.
2
Induction chemotherapy followed by concurrent radio-chemotherapy versus concurrent radio-chemotherapy alone as treatment of locally advanced squamous cell carcinoma of the head and neck (HNSCC): A meta-analysis of randomized trials.诱导化疗后序贯同步放化疗与单纯同步放化疗治疗局部晚期头颈部鳞状细胞癌（HNSCC）的比较：一项随机试验的荟萃分析。
Radiother Oncol. 2016 Feb;118(2):238-43. doi: 10.1016/j.radonc.2015.10.014. Epub 2015 Nov 14.
3
A prospective phase II randomized study of docetaxel combined with lobaplatin versus TPF regimen induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced head and neck squamous cell carcinoma.一项多西他赛联合洛铂对比 TPF 方案诱导化疗后同期放化疗治疗局部晚期头颈部鳞癌的前瞻性 II 期随机研究。
J Cancer Res Clin Oncol. 2023 Dec;149(20):18081-18091. doi: 10.1007/s00432-023-05497-1. Epub 2023 Nov 20.
4
Induction chemotherapy plus IMRT alone versus induction chemotherapy plus IMRT-based concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective cohort study.局部晚期鼻咽癌诱导化疗加 IMRT 与诱导化疗加基于 IMRT 的同期放化疗的回顾性队列研究。
J Cancer Res Clin Oncol. 2019 Jul;145(7):1857-1864. doi: 10.1007/s00432-019-02925-z. Epub 2019 May 6.
5
Comparison of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by radiation vs concurrent chemoradiotherapy with TPF in patients with locally advanced squamous cell carcinoma of the head and neck.多西他赛、顺铂和5-氟尿嘧啶诱导化疗（TPF）后放疗与TPF同步放化疗治疗局部晚期头颈部鳞状细胞癌患者的比较
Clin Oncol (R Coll Radiol). 2005 May;17(3):148-52. doi: 10.1016/j.clon.2004.09.013.
6
Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma.局部晚期口腔鳞状细胞癌TPF诱导化疗后手术及放疗的随机III期试验的长期结果
Oncotarget. 2015 Jul 30;6(21):18707-14. doi: 10.18632/oncotarget.4531.
7
Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer.卡铂-紫杉醇与多西他赛-顺铂-5-氟尿嘧啶诱导化疗后同期放化疗治疗局部晚期头颈部癌的比较。
Oral Oncol. 2014 Jan;50(1):52-8. doi: 10.1016/j.oraloncology.2013.08.007. Epub 2013 Sep 19.
8
Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma.新辅助化疗后序贯同步放化疗治疗局部晚期鼻咽癌。
Chin J Cancer. 2010 May;29(5):551-5. doi: 10.5732/cjc.009.10518.
9
Neoadjuvant docetaxel, cisplatin, 5-fluorouracil before concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck versus concomitant chemoradiotherapy: a phase II feasibility study.在局部晚期头颈部鳞状细胞癌中，新辅助多西他赛、顺铂、5-氟尿嘧啶序贯同步放化疗与同步放化疗的比较：一项II期可行性研究。
Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):481-7. doi: 10.1016/j.ijrobp.2003.10.055.
10
Locally advanced squamous cell carcinoma of the head and neck: A systematic review and Bayesian network meta-analysis of the currently available treatment options.局部晚期头颈部鳞状细胞癌：当前治疗方案的系统评价和贝叶斯网络荟萃分析。
Oral Oncol. 2018 May;80:40-51. doi: 10.1016/j.oraloncology.2018.03.001. Epub 2018 Mar 27.

引用本文的文献

1
Necrosis of the Tongue as a Late Complication of Radiotherapy.舌坏死作为放疗的晚期并发症
Iran J Otorhinolaryngol. 2023 Sep;35(130):285-288. doi: 10.22038/IJORL.2023.67124.3305.

本文引用的文献

1
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
2
Open label, Non-randomized, Interventional Study to Evaluate Response Rate After Induction Therapy with Docetaxel and Cisplatin in Locally Advanced Squamous Cell Carcinoma of Oral Cavity.一项开放标签、非随机、干预性研究，旨在评估多西他赛和顺铂诱导治疗局部晚期口腔鳞状细胞癌后的缓解率。
Gulf J Oncolog. 2020 Jan;1(32):12-28.
3
Induction TPF followed by concomitant treatment versus concomitant treatment alone in locally advanced head and neck cancer. A phase II-III trial.
诱导 TPF 后同期放化疗与单纯同期放化疗治疗局部晚期头颈部鳞癌的 II-III 期随机对照临床研究。
Ann Oncol. 2017 Sep 1;28(9):2206-2212. doi: 10.1093/annonc/mdx299.
4
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.局部晚期头颈部癌诱导化疗后同期放化疗（序贯放化疗）与单纯同期放化疗比较（PARADIGM）：一项随机 3 期试验。
Lancet Oncol. 2013 Mar;14(3):257-64. doi: 10.1016/S1470-2045(13)70011-1. Epub 2013 Feb 13.
5
Betel chewing and public health.嚼槟榔与公共卫生。
Asia Pac J Public Health. 2011 Nov;23(6):1021-4. doi: 10.1177/1010539511428690.
6
Areca users in combination with tobacco and alcohol use are associated with younger age of diagnosed esophageal cancer in Taiwanese men.在台湾男性中，与嚼食槟榔并同时使用烟草和酒精的患者相比，年龄较小即被诊断患有食管癌的患者与嚼食槟榔相关。
PLoS One. 2011;6(10):e25347. doi: 10.1371/journal.pone.0025347. Epub 2011 Oct 19.
7
Smokeless tobacco use in Pakistan and its association with oropharyngeal cancer.巴基斯坦的无烟烟草使用及其与口咽癌的关联。
East Mediterr Health J. 2010;16 Suppl:S24-30.
8
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
9
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
10
Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial.顺铂和氟尿嘧啶单药或联合多西他赛诱导化疗治疗局部晚期头颈部鳞状细胞癌：TAX 324 随机 3 期试验的长期结果。
Lancet Oncol. 2011 Feb;12(2):153-9. doi: 10.1016/S1470-2045(10)70279-5. Epub 2011 Jan 11.