Li Feng
Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
J Exp Nephrol. 2021;2(1):3-6. doi: 10.46439/nephrology.2.007.
Vitamin B12 (B12) is required for cellular metabolism and DNA synthesis as a co-enzyme; it also possesses anti-reactive oxygen species (ROS) property as a superoxide scavenger. B12 deficiency has been implicated in multiple diseases such as megaloblastic anemia, and this disease can be effectively cured by supplementation of B12. Multiple studies suggest that B12 also benefits the conditions associated with excess ROS. Recently, we have reported that oral high dose B12 decreases superoxide level and renal injury induced by ischemia/reperfusion in mice. Here, we discuss potential mechanism(s) other than decreasing superoxide by which B12 executes its beneficial effects.
维生素B12（B12）作为一种辅酶，参与细胞代谢和DNA合成；它还具有作为超氧化物清除剂的抗活性氧（ROS）特性。B12缺乏与多种疾病有关，如巨幼细胞贫血，补充B12可有效治愈该疾病。多项研究表明，B12对与ROS过多相关的病症也有益处。最近，我们报道口服高剂量B12可降低小鼠缺血/再灌注诱导的超氧化物水平和肾损伤。在此，我们讨论B12发挥其有益作用的除降低超氧化物之外的潜在机制。
