Department of Ophthalmology, Ankara Bilkent City Hospital, Ankara, Turkey.
Department of Ophthalmology, Denizli State Hospital, Denizli, Turkey.
Int Ophthalmol. 2021 Dec;41(12):3929-3933. doi: 10.1007/s10792-021-01962-3. Epub 2021 Jul 22.
To compare optical coherence tomography angiography (OCTA) findings in cases with migraine and healthy controls.
Thirty-eight eyes of 19 patients with migraine with aura and 38 eyes of 19 healthy subjects were enrolled in this prospective and comparative study. All patients and healthy controls were evaluated with OCTA (Triton, Topcon®, Tokyo, Japan). Central macular thickness (CMT), optic disc parameters (such as retinal nerve fibre layer [RNFL] thickness and rim and disc areas), foveal avascular zone (FAZ) and parafoveal superficial vessel density (VD) measurements were analysed.
The optic disc rim area was significantly larger in the migraine group compared to the control group (p = 0.009). In OCTA measurements, the FAZ area was significantly larger in migraine patients (p = 0.001). The parafoveal superficial VD measurements were found to be lower in the migraine patients in all quadrants, but not statistically significant. Weak negative correlations were found between superior parafoveal VD and disease duration in migraine patients.
Migraine with aura was associated with optic disc rim changes, but without any remarkable foveal vascular decrements. It is possible for migraine to cause structural changes due to its chronic nature.
比较偏头痛患者和健康对照者的光学相干断层扫描血管造影（OCTA）结果。
本前瞻性对照研究纳入了 19 例偏头痛伴先兆患者的 38 只眼和 19 例健康对照者的 38 只眼。所有患者和健康对照者均接受 OCTA（Triton，Topcon®，东京，日本）检查。分析中央黄斑厚度（CMT）、视盘参数（如视网膜神经纤维层[RNFL]厚度和视盘边缘和面积）、中心凹无血管区（FAZ）和旁中心凹浅层血管密度（VD）测量值。
与对照组相比，偏头痛组的视盘边缘面积明显更大（p=0.009）。在 OCTA 测量中，偏头痛患者的 FAZ 面积明显更大（p=0.001）。偏头痛患者各象限的旁中心凹浅层 VD 测量值均较低，但无统计学意义。偏头痛患者的上旁中心凹浅层 VD 与疾病持续时间呈负弱相关。
偏头痛伴先兆与视盘边缘改变有关，但无明显的中心凹血管减少。偏头痛的慢性性质可能导致结构变化。
