Yadav Tanya, Panigrahi Pradeep Kumar, Pattnaik Lolly, Sahoo Lulup Kumar
Department of Ophthalmology, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India.
Department of Neurology, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India.
Indian J Ophthalmol. 2025 Jun 1;73(6):900-905. doi: 10.4103/IJO.IJO_2300_24. Epub 2025 May 28.
Assessment of peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head (ONH), and macular parameters using spectral domain optical coherence tomography (OCT) in migraine patients and comparison with age- and gender-matched healthy comparable patients.
Patients diagnosed with migraines who fulfilled the inclusion criteria were included in the study. Healthy subjects without any ocular and systemic disorders constituted the control group. pRNFL thickness, ONH, and macular parameters were assessed using spectral domain OCT in all patients. The various study parameters were analyzed and compared between the two groups at the end of the study period. The migraine patients were also analyzed based on type, duration, and severity of migraine.
The study included 100 migraine patients and 100 age- and sex-matched healthy subjects. The mean age in migraine and control groups was 31.01 ± 8.56 and 30.80 ± 8.65 years, respectively. Females comprised 84% of the study subjects. Migraine patients had statistically significant (P < 0.05) thinner pRNFL and macular parameters compared to healthy subjects. Chronic migraine, severe migraine, and duration of more than 5 years were associated with statistically significant thinner pRNFL and macular parameters.
Migraine patients have significantly thinner pRNFL and macular parameters than healthy patients, and this is especially so for patients with greater severity of migraine.
使用频域光学相干断层扫描（OCT）评估偏头痛患者的视乳头周围视网膜神经纤维层（pRNFL）厚度、视神经乳头（ONH）和黄斑参数，并与年龄和性别匹配的健康对照患者进行比较。
纳入符合纳入标准的偏头痛诊断患者。无任何眼部和全身疾病的健康受试者构成对照组。所有患者均使用频域OCT评估pRNFL厚度、ONH和黄斑参数。在研究期结束时分析并比较两组之间的各种研究参数。还根据偏头痛的类型、持续时间和严重程度对偏头痛患者进行分析。
该研究纳入了100例偏头痛患者和100例年龄和性别匹配的健康受试者。偏头痛组和对照组的平均年龄分别为31.01±8.56岁和30.80±8.65岁。女性占研究对象的84%。与健康受试者相比，偏头痛患者的pRNFL和黄斑参数在统计学上显著变薄（P<0.05）。慢性偏头痛、重度偏头痛以及病程超过5年与pRNFL和黄斑参数在统计学上显著变薄相关。
偏头痛患者的pRNFL和黄斑参数明显比健康患者薄，对于偏头痛严重程度较高的患者尤其如此。
