Beyer G A, Lipman B T, Haughton V M, Ho K C
Department of Radiology, Medical College of Wisconsin, Milwaukee 53226.
Invest Radiol. 1987 Oct;22(10):781-5. doi: 10.1097/00004424-198710000-00003.
A model for studying the relationship between chronic arachnoiditis and pain sensitivity was developed. Thirty male ICR mice were randomly divided into three groups and the tail-flick test was done using an EMDIE-TF6 apparatus (Emdie Instrument Co., Montpelier, VA). Ten mice were injected intrathecally with 5.0 microL of a kaolin-metrizamide mixture and ten control mice were injected intrathecally with 5.0 microL of an electrolyte solution resembling CSF. A third group, (naive controls) were given no treatment. Six weeks later tail-flick tests were repeated. The kaolin-treated mice had significantly decreased tail-flick latencies (P less than .05) compared with the baseline; the controls had no significant change in tail-flick latency. Histologic examination revealed moderate to severe arachnoiditis in the kaolin-treated animals and no evidence of arachnoid abnormalities in the controls. This study suggests that arachnoiditis may be associated with decreased pain thresholds.
建立了一个用于研究慢性蛛网膜炎与疼痛敏感性之间关系的模型。30只雄性ICR小鼠被随机分为三组，使用EMDIE-TF6仪器（Emdie仪器公司，弗吉尼亚州蒙彼利埃）进行甩尾试验。10只小鼠鞘内注射5.0微升高岭土-甲泛葡胺混合物，10只对照小鼠鞘内注射5.0微升类似脑脊液的电解质溶液。第三组（未处理对照）不进行处理。六周后重复甩尾试验。与基线相比，高岭土处理的小鼠甩尾潜伏期显著缩短（P<0.05）；对照组甩尾潜伏期无显著变化。组织学检查显示高岭土处理的动物有中度至重度蛛网膜炎，而对照组无蛛网膜异常迹象。这项研究表明，蛛网膜炎可能与疼痛阈值降低有关。
