Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA.
Department of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Cytoskeleton (Hoboken). 2021 Jun;78(6):312-322. doi: 10.1002/cm.21680. Epub 2021 Jul 28.
Alterations to the mechanical properties of the microenvironment are a hallmark of cancer. Elevated mechanical stresses exist in many solid tumors and elicit responses from cancer cells. Uncontrolled growth in confined environments gives rise to elevated solid compressive stress on cancer cells. Recruitment of leaky blood vessels and an absence of functioning lymphatic vessels causes a rise in the interstitial fluid pressure. Here we review the role of the cancer cell cytoskeleton and the nucleus in mediating both the initial and adaptive cancer cell response to these two types of mechanical stresses. We review how these mechanical stresses alter cancer cell functions such as proliferation, apoptosis, and migration.
微环境力学性质的改变是癌症的一个标志。许多实体瘤中存在较高的机械应力，这些应力会引发癌细胞的反应。在有限的环境中不受控制的生长会导致癌细胞受到较高的固体压缩应力。渗漏性血管的募集和功能性淋巴管的缺失导致间质液压力升高。在这里，我们回顾了癌细胞骨架和细胞核在介导这两种类型的机械应力对癌细胞的初始和适应性反应中的作用。我们回顾了这些机械应力如何改变癌细胞的功能，如增殖、凋亡和迁移。
