纳皮尔霉素的生物合成。
Biosynthesis of napyradiomycins.
作者信息
Shiomi K, Iinuma H, Naganawa H, Isshiki K, Takeuchi T, Umezawa H
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1987 Dec;40(12):1740-5. doi: 10.7164/antibiotics.40.1740.
PMID:3429338
Abstract
Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.
摘要
基于[2-¹³C]乙酸盐和[1,2-¹³C]乙酸盐的掺入，开展了对萘纳霉素的生物合成研究。乙酸盐单元的排列表明，萘纳霉素的B环和C环源自一个五酮化合物，而A环和侧链可能由甲羟戊酸合成。
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