Qassem Tarik, Khater Mohamed S, Emara Tamer, Rasheedy Doha, Tawfik Heba M, Mohammedin Ahmed S, Tolba Mohammad F, Aly El-Gabry Dina, Abdel Aziz Karim, Saber Heba G
Maudsley Health, Al-Amal Psychiatric Hospital, Dubai, United Arab Emirates.
Neuropsychiatry Department, Okasha Institute of Psychiatry, Ain Shams University, Cairo, Egypt.
Dement Geriatr Cogn Disord. 2021;50(2):178-182. doi: 10.1159/000517580. Epub 2021 Jul 22.
Mild cognitive impairment (MCI) represents a target for early detection and intervention in dementia, yet there is a shortage of validated screening tools in Arabic to diagnose MCI. The mini-Addenbrooke's Cognitive Examination (m-ACE) is a brief cognitive battery that is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition.
We aimed to validate the m-ACE in Arabic speakers in Egypt with MCI to provide cut-off scores.
We included 24 patients with MCI and 52 controls and administered the Arabic version of the m-ACE.
There was a statistically significant difference (p < 0.0001) on the total m-ACE score between MCI patients (mean 18.54, SD 3.05) and controls (mean 24.54, SD 2.68). There was also a statistically significant difference between MCI patients and controls on the total score and the fluency, visuospatial, and memory recall sub-scores of the m-ACE (p < 0.05). Performance on the m-ACE significantly correlated with both the Mini-Mental State Examination (MMSE) and the Addenbrooke's Cognitive Examination-III (ACE-III). Using a receiver operator characteristic curve, the optimal cut-off score for MCI on the m-ACE total score was 21 out of 30 (87.5% sensitivity, 84.6% specificity, and 85.5% accuracy).
We validated the Arabic m-ACE in Egyptian patients with MCI and provided objective validation of it as a screening tool for MCI, with good sensitivity, specificity, and accuracy that is comparable to other translated versions of the m-ACE in MCI.
轻度认知障碍（MCI）是痴呆症早期检测和干预的目标，但阿拉伯语中缺乏经过验证的用于诊断MCI的筛查工具。简易版Addenbrooke认知检查量表（m-ACE）是一种简短的认知测试组合，满分30分，可在5分钟内完成，为认知评估提供了一种快速筛查工具。
我们旨在验证m-ACE在埃及患有MCI的阿拉伯语使用者中的有效性，并提供临界值。
我们纳入了24例MCI患者和52例对照，并实施了阿拉伯语版的m-ACE。
MCI患者（平均18.54，标准差3.05）和对照（平均24.54，标准差2.68）的m-ACE总分存在统计学显著差异（p < 0.0001）。MCI患者与对照在m-ACE的总分以及流畅性、视觉空间和记忆回忆子分数方面也存在统计学显著差异（p < 0.05）。m-ACE的表现与简易精神状态检查表（MMSE）和Addenbrooke认知检查量表第三版（ACE-III）均显著相关。使用受试者工作特征曲线，m-ACE总分诊断MCI的最佳临界值为30分中的21分（灵敏度87.5%，特异度84.6%，准确度85.5%）。
我们在埃及患有MCI的患者中验证了阿拉伯语版m-ACE，并客观验证了其作为MCI筛查工具的有效性，其具有良好的灵敏度、特异度和准确度，与MCI中m-ACE的其他翻译版本相当。
