Polkowska Agnieszka, Szczepaniak Izabela, Bossowski Artur
Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Ulica Kilińskiego 1, 15-089 Białystok, Poland; Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Children's University Hospital in Białystok, Ulica Waszyngtona 17, 15-274 Białystok, Poland.
Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Ulica Kilińskiego 1, 15-089 Białystok, Poland.
Biomed Res Int. 2016;2016:8379294. doi: 10.1155/2016/8379294. Epub 2016 Jan 19.
The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study involved 80 children aged 4-18 years (M/F -37/43). Children with type 1 diabetes (n = 46) were compared to the control group (n = 34). The study group was divided into 4 subgroups: (I) patients with newly diagnosed type 1 diabetes, after an episode of ketoacidosis (n = 10), (II) patients with type 1 diabetes of duration no longer than 5 years (n = 9), (III) patients with 5 to 10 years of DT1 (n = 20), and (IV) patients with type 1 diabetes of duration longer than 10 years (n = 7). The concentrations of gastric peptide and adipocytokines across all subgroups were lower than in the control group. The differences were statistically significant (p < 0.0001), which may be of importance in the development of the disease complications.
对胃肽和脂肪因子在体内功能的了解日益增加，这使得人们推测它们在很大程度上通过调节葡萄糖代谢和胰岛素抵抗，在连接食物摄入、营养状况和身体生长过程中发挥主要作用。本研究的目的是评估1型糖尿病患儿血清中所选胃肽和脂肪细胞因子的水平，并探讨其与病程的关系。该研究纳入了80名4 - 18岁的儿童（男/女 = 37/43）。将1型糖尿病患儿（n = 46）与对照组（n = 34）进行比较。研究组分为4个亚组：（I）新发1型糖尿病且伴有酮症酸中毒发作的患者（n = 10），（II）病程不超过5年的1型糖尿病患者（n = 9），（III）病程为5至10年的1型糖尿病患者（n = 20），以及（IV）病程超过10年的1型糖尿病患者（n = 7）。所有亚组中胃肽和脂肪细胞因子的浓度均低于对照组。差异具有统计学意义（p < 0.0001），这可能对疾病并发症的发生具有重要意义。
