Gungor Meltem, Kurutas Ergul Belge, Oner Erkan, Unsal Velid, Altun Hatice, Yalin Ali Erdinc, Yalin Serap, Bozkus Ozlem, Sahin Nilfer
Department of Medical Biochemistry, Faculty of Medicine, Sanko University, Gaziantep, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Sutcu Imam University, Kahramanmaras, Turkey.
Clin Psychopharmacol Neurosci. 2021 Aug 31;19(3):530-536. doi: 10.9758/cpn.2021.19.3.530.
Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD.
A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6-12 years; male/female: 20/15) and 35 healthy controls (age: 6-12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit.
The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively.
This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR.
注意力缺陷多动障碍（ADHD）是一种异质性、高度可遗传的常见儿童神经行为障碍，由复杂的基因-基因和基因-环境相互作用引起。促红细胞生成素（Epo）/促红细胞生成素受体（EpoR）系统在非造血组织中具有其他重要功能。在本研究中，我们旨在调查Epo和EpoR的水平及其在ADHD儿童中的诊断价值。
本研究共纳入70名儿童，35名未接受过药物治疗的ADHD患者（年龄：6 - 12岁；男/女：20/15）和35名健康对照（年龄：6 - 12岁；男/女：22/13）。使用商用夹心酶联免疫吸附测定试剂盒测定血清Epo和EpoR水平。
结果表明，与对照组相比，ADHD患者的Epo水平降低（p < 0.05）。另一方面，这些患者的EpoR水平升高（p < 0.05）。此外，ADHD患者的Epo/EpoR比值显著低于对照组（p < 0.05）。受试者工作特征曲线分析显示Epo和EpoR具有较高的诊断性能，曲线下面积分别为0.980和1.000。
这是第一份研究ADHD患者血清Epo和EpoR水平之间关联的报告。我们的结果表明，Epo可能在ADHD的病因中起作用，并且如果在ADHD儿童的常规治疗基础上给予Epo治疗，可能对这些疾病有益。此外，我们的结果揭示了Epo和EpoR可能的诊断价值。
