通过D-木糖吸收试验评估轮状病毒感染新生小鼠的肠道损伤。
Assessment of intestinal damage in rotavirus infected neonatal mice by a D-xylose absorption test.
作者信息
Ijaz M K, Sabara M I, Frenchick P J, Babiuk L A
机构信息
Veterinary Infectious Disease Organization (VIDO), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
出版信息
J Virol Methods. 1987 Nov;18(2-3):153-7. doi: 10.1016/0166-0934(87)90120-0.
Abstract
A D-xylose absorption test has been standardized for use in newborn mice. It was used to measure small intestine dysfunction in neonate mice following infection with various isolates of rotaviruses. A xylose dose of 1 mg/g body weight was required to produce a maximum level of 100 micrograms/100 microliters of plasma 2 h after administration of D-xylose. The mice inoculated with rotavirus absorbed significantly less D-xylose compared with uninoculated control mice. A micromethod is described which proved to be suitable to quantitate D-xylose for determination of absorptive function of the small intestine in small animals such as newborn mice.
摘要
已对D-木糖吸收试验进行标准化，以用于新生小鼠。该试验用于测量新生小鼠感染各种轮状病毒分离株后小肠功能障碍。给予D-木糖后2小时，需要1mg/g体重的木糖剂量才能使血浆中木糖水平达到最高100微克/100微升。与未接种的对照小鼠相比，接种轮状病毒的小鼠吸收的D-木糖明显减少。本文描述了一种微量法，该方法被证明适用于定量测定新生小鼠等小动物小肠吸收功能的D-木糖。
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