Tanaka Kyohei, Kinno Ryuta, Muragaki Yoshihiro, Maruyama Takashi, Sakai Kuniyoshi L
Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan.
Department of Neurosurgery, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
Cereb Cortex Commun. 2020 Sep 1;1(1):tgaa061. doi: 10.1093/texcom/tgaa061. eCollection 2020.
Analysis of the functional connectivity has enabled understanding of the cortical networks. In the present study, we used a picture-sentence matching task to introduce syntactically harder conditions, and clarified 3 major points. First, patients with a glioma in the lateral premotor cortex/inferior frontal gyrus or in other cortical regions showed much weaker activations than controls, especially in the left inferior frontal gyrus. Moreover, the error rates under the harder conditions were much higher for these patients. Secondly, syntactic loads induced selective connectivity with enhancement and suppression, consistently for both patients and controls. More specifically, the local connectivity was enhanced among the 3 syntax-related networks within the left frontal cortex, while the global connectivity of both dorsal and ventral pathways was suppressed. In addition, the exact reproducibility of -values across the control and patient groups was remarkable, since under easier conditions alone, connectivity patterns for the patients were completely unmatched with those for the controls. Thirdly, we found an additional syntax-related network, further confirming the intergroup similarity of task-induced functional connectivity. These results indicate that functional connectivity of agrammatic patients is mostly preserved regardless of a glioma, and that the connectivity can change dynamically and systematically according to syntactic loads.
对功能连接性的分析有助于理解皮层网络。在本研究中，我们使用图片-句子匹配任务引入句法难度更高的条件，并阐明了三个要点。首先，外侧运动前区皮质/额下回或其他皮质区域患有胶质瘤的患者表现出比对照组弱得多的激活，尤其是在左侧额下回。此外，这些患者在难度更高的条件下错误率要高得多。其次，句法负荷在患者和对照组中均一致地诱导了具有增强和抑制作用的选择性连接。更具体地说，左侧额叶皮质内的三个句法相关网络之间的局部连接增强，而背侧和腹侧通路的全局连接均受到抑制。此外，对照组和患者组之间p值的精确可重复性非常显著，因为仅在较容易的条件下患者的连接模式就与对照组完全不匹配。第三，我们发现了一个额外的句法相关网络，进一步证实了任务诱导的功能连接性在组间的相似性。这些结果表明，语法缺失患者的功能连接性大多不受胶质瘤影响而得以保留，并且这种连接性会根据句法负荷动态且系统地发生变化。
