Chen Yufen, Herrold Amy A, Martinovich Zoran, Bari Sumra, Vike Nicole L, Blood Anne J, Walter Alexa E, Harezlak Jaroslaw, Seidenberg Peter H, Bhomia Manish, Knollmann-Ritschel Barbara, Stetsiv Khrystyna, Reilly James L, Nauman Eric A, Talavage Thomas M, Papa Linda, Slobounov Semyon, Breiter Hans C
Center for Translational Imaging, Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Edward Hines Jr., VA Hospital, Research Service, Hines, IL 60141, USA.
Cereb Cortex Commun. 2020 Oct 26;1(1):tgaa078. doi: 10.1093/texcom/tgaa078. eCollection 2020.
Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of "imaging omics." Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel's test < 0.05) between abnormal miRNA levels and compromised Balance scores. Given the involvement of these miRNAs in inflammation and immune function and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model in these athletes with 11 years of average football exposure. rCBF, a systems biology measure, was necessary for miRNA to affect behavior.
在一项“成像组学”的新颖演示中，运用中介分析整合了转录组学、局部脑血流量（rCBF）以及基于虚拟现实的空间运动任务。在全国大学体育协会（NCAA）第一分区的橄榄球运动员中收集的数据显示，在赛季前训练前被批准参赛的运动员身上存在显著关系：1）miR - 30d和miR - 92a水平升高与壳核rCBF升高有关；2）壳核rCBF升高与平衡分数受损有关；3）平衡分数受损与微小RNA（miRNA）水平升高有关。rCBF在异常miRNA水平和受损平衡分数之间充当了一致的中介变量（索贝尔检验＜0.05）。鉴于这些miRNA参与炎症和免疫功能，且血管灌注是炎症反应的一个组成部分，这些发现支持了这些平均有11年橄榄球运动经历的运动员存在慢性炎症模型。rCBF作为一种系统生物学指标，是miRNA影响行为所必需的。
