Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
BMC Cancer. 2018 Nov 29;18(1):1189. doi: 10.1186/s12885-018-4907-3.
Recently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in various carcinomas.
Literature searches of seven electronic databases were performed for eligible articles of the prognostic role of miR-20a in human cancers. Hazard ratios (HR) for overall survival (OS), disease free survival (DFS), progression-free survival (PFS) as well as their 95% confidence intervals (95%CIs) were used to assess the influence of miR-20a expression on patient prognosis. Odds ratio (OR) and 95%CIs were applied to evaluate the correlation between miR-20a expression and clinicopathological characteristics.
Based on the OS analyzed by log rank tests, there was a significant association between miR-20a levels and OS by fixed effects model. By subgroup analyses, the significance was also observed in the studies of specimen derived from blood and gastrointestinal cancer group. The independent prognostic role of miR-20a expression for the OS was observed significantly by fixed effects model. In addition, we observed significant association between miR-20a expression levels and DFS of log rank tests, DFS of cox regression. Significant relation of gender/differentiation and the expression level of miR-20a was identified.
Base on the findings, the elevated miR-20a expression level is related to poor prognosis of gastrointestinal cancer patients. As for other types of carcinomas, the results are still not stable and more studies are required to further identify miR-20a prognostic values. In addition, miR-20a expression level is relatively higher in women than that in men, and increased miR-20a expression level is linked to poor tumor differentiation.
最近，miR-20a（miR-20a）已被报道影响临床特征，并可能在人类癌症中具有预后价值。本荟萃分析评估了 miR-20a 在各种癌症中的预后作用。
对七个电子数据库中的合格文献进行了 miR-20a 表达与人类癌症患者预后相关性的文献检索。使用风险比（HR）评估 miR-20a 表达对患者预后的影响，包括总生存期（OS）、无病生存期（DFS）、无进展生存期（PFS）及其 95%置信区间（95%CI）。采用比值比（OR）及其 95%CI 评估 miR-20a 表达与临床病理特征的相关性。
基于对数秩检验分析的 OS，固定效应模型显示 miR-20a 水平与 OS 之间存在显著相关性。亚组分析中，在血液和胃肠道癌症组的研究中也观察到了这种意义。固定效应模型显示 miR-20a 表达对 OS 的独立预后作用。此外，我们还观察到 miR-20a 表达水平与 DFS 的对数秩检验和 COX 回归的 DFS 之间存在显著关联。还发现 miR-20a 表达水平与性别/分化显著相关。
基于这些发现，升高的 miR-20a 表达水平与胃肠道癌症患者的不良预后相关。对于其他类型的癌症，结果仍然不稳定，需要更多的研究来进一步确定 miR-20a 的预后价值。此外，miR-20a 表达水平在女性中相对较高，而在男性中较低，并且 miR-20a 表达水平的增加与肿瘤分化不良有关。
