Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Chem Commun (Camb). 2021 Aug 12;57(65):8059-8062. doi: 10.1039/d1cc02861h.
In this paper, an asymmetric allylic alkylation of easily available azomethine ylides with Morita-Baylis-Hillman (MBH) carbonates through a copper (i)/Lewis base cooperative catalysis strategy has been realized. The co-catalyzed asymmetric allylic alkylation provided the corresponding amino acid derivatives in up to 90% yields with up to 99% ee as well as good to excellent regioselectivity.
本文通过铜（i）/路易斯碱协同催化策略，实现了易得的亚胺叶立德与 Morita-Baylis-Hillman（MBH）碳酸酯的不对称烯丙基烷基化反应。协同催化的不对称烯丙基烷基化反应以高达 90%的收率和高达 99%的对映选择性以及良好至优秀的区域选择性，提供了相应的氨基酸衍生物。
