铜/路易斯碱协同催化亚胺叶立德与 Morita-Baylis-Hillman 碳酸酯的不对称烯丙基烷基化反应。
Copper/Lewis base cooperatively catalyzed asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with azomethine ylides.
机构信息
Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
出版信息
Chem Commun (Camb). 2021 Aug 12;57(65):8059-8062. doi: 10.1039/d1cc02861h.
In this paper, an asymmetric allylic alkylation of easily available azomethine ylides with Morita-Baylis-Hillman (MBH) carbonates through a copper (i)/Lewis base cooperative catalysis strategy has been realized. The co-catalyzed asymmetric allylic alkylation provided the corresponding amino acid derivatives in up to 90% yields with up to 99% ee as well as good to excellent regioselectivity.
本文通过铜（i）/路易斯碱协同催化策略，实现了易得的亚胺叶立德与 Morita-Baylis-Hillman（MBH）碳酸酯的不对称烯丙基烷基化反应。协同催化的不对称烯丙基烷基化反应以高达 90%的收率和高达 99%的对映选择性以及良好至优秀的区域选择性，提供了相应的氨基酸衍生物。
Zotero 插件