Duan Zhi-Wen, Wang Shuang-Yan, Pang Xu, Zhang Jie, Zhao Ye, Zheng Xiao-Hui, Ma Bai-Ping
Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China.
College of Life Sciences, Northwest University Xi'an 710069, China.
Zhongguo Zhong Yao Za Zhi. 2021 Jun;46(11):2830-2836. doi: 10.19540/j.cnki.cjcmm.20210222.601.
Fifteen compounds were isolated from the 70% EtOH extract of leaves of Chinese hawthorn(Crataegus pinnatifida var. major) by various purification steps, and their structures were determined as 2α,3α,12β,19α,-tetrahydroxyursan-13β,28-olide(1),euscaphic acid(2), tormentic acid(3), ursolic acid(4), pomolic acid(5), corosolic acid(6), maslinic acid(7), linalyl rutinoside(8),(Z)-3-hexenyl β-D-glucoside(9),(3S, 6S)-cis-linalool-3,7-oxide-β-D-glucopyranoside(10), pisumionoside(11), icariside B6(12), byzantionoside B(13),(6R,7E,9R)-9-Hydroxy-4,7-megastigmadien-3-one 9-O-β-D-glucopyranoside(14) and(6S,7E,9R)-6,9-dihydroxy-4,7-megastigmadien-3-one 9-O-β-D-glucopyranoside(15) mainly based on the mass spectrum(MS) and nuclear magnetic resonance(NMR) spectroscopic techniques, of which compound 1 was a new pentacyclic triterpene, and compounds 2, 5, 6, 8, 10, 13 and 15 were isolated form this plant for the first time.
通过多种纯化步骤从山里红（Crataegus pinnatifida var. major）叶的70%乙醇提取物中分离出15种化合物，主要基于质谱（MS）和核磁共振（NMR）光谱技术确定它们的结构分别为2α,3α,12β,19α - 四羟基乌苏烷 - 13β,28 - 内酯（1）、野鸦椿酸（2）、 tormentic酸（3）、熊果酸（4）、委陵菜酸（5）、科罗索酸（6）、齐墩果酸（7）、芳樟醇芸香糖苷（8）、(Z)-3 - 己烯基β - D - 葡萄糖苷（9）、(3S, 6S)-顺式芳樟醇 - 3,7 - 氧化物 - β - D - 葡萄糖吡喃糖苷（10）、豌豆苷（11）、淫羊藿苷B6（12）、拜占庭糖苷B（13）、(6R,7E,9R)-9 - 羟基 - 4,7 - 大戟二烯 - 3 - 酮9 - O - β - D - 葡萄糖吡喃糖苷（14）和(6S,7E,9R)-6,9 - 二羟基 - 4,7 - 大戟二烯 - 3 - 酮9 - O - β - D - 葡萄糖吡喃糖苷（15），其中化合物1是一种新的五环三萜，化合物2、5、6、8、10、13和15首次从该植物中分离得到。
