Ding Ying, Long Jinguo, Sun Feilong, Fang Xianjie
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Org Lett. 2021 Aug 6;23(15):6073-6078. doi: 10.1021/acs.orglett.1c02143. Epub 2021 Jul 23.
Herein reported is a nickel-catalyzed isomerization/allylic cyanation of alkenyl alcohols, which complements current methods for the allylic substitution reactions. The specific diphosphite ligand and methanol as the solvent are crucial for the success for this transformation. A gram-scale regioconvergent experiment and formal synthesis of quebrachamine demonstrate the high potential of this methodology.
本文报道了一种镍催化的链烯醇异构化/烯丙基氰化反应，该反应补充了当前用于烯丙基取代反应的方法。特定的双膦配体和甲醇作为溶剂对于该转化的成功至关重要。克级区域收敛实验和克百定的形式合成证明了该方法的高潜力。
