Joffe R T, Swinson R P
Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada.
J Clin Psychopharmacol. 1987 Dec;7(6):420-2.
An acute methylphenidate challenge was performed on 13 patients with primary obsessive-compulsive disorder. There was no overall effect of methylphenidate on mood or obsessive-compulsive behavior. However, on various behavioral scales, four patients had an antiobsessive-compulsive response and one patient an antidepressant response to methylphenidate. The clinical and theoretical implications of these findings are discussed.
对13例原发性强迫症患者进行了急性哌甲酯激发试验。哌甲酯对情绪或强迫行为没有总体影响。然而，在各种行为量表上，4例患者对哌甲酯有抗强迫反应，1例患者有抗抑郁反应。讨论了这些发现的临床和理论意义。
