The Jackson Laboratory, Bar Harbor, ME, USA.
Geroscience. 2021 Oct;43(5):2129-2137. doi: 10.1007/s11357-021-00421-2. Epub 2021 Jul 23.
Healthspan is a complex trait, influenced by many genes and environmental factors that accelerate or delay aging, reduce or increase disease risk, and extend or reduce lifespan. Thus, assessing the role of genetic variation in aging requires an experimental strategy capable of modeling the genetic and biological complexity of human populations. The goal of the The Jackson Laboratory Nathan Shock Center (JAX NSC) is to provide research resources and training for geroscience investigators that seek to understand the role of genetics and genetic diversity on the fundamental process of aging and diseases of human aging using the laboratory mouse as a model system. The JAX NSC has available novel, deeply characterized populations of aged mice, performs state-of-the-art phenotyping of age-relevant traits, provides systems genetics analysis of complex data sets, and provides all of these resources to the geroscience community. The aged animal resources, phenotyping capacity, and genetic expertise available through the JAX NSC benefit the geroscience community by fostering cutting-edge, novel lines of research that otherwise would not be possible. Over the past 15 years, the JAX NSC has transformed aging research across the geroscience community, providing aging mouse resources and tissues to researchers. All JAX NSC data and tools are publicly disseminated on the Mouse Phenome Database and the JAX NSC website, thus ensuring that the resources generated and expertise acquired through the Center are readily available to the aging research community. The JAX NSC will continue to enhance its ability to perform innovative research using a mammalian model to illuminate novel genotype-phenotype relationships and provide a rational basis for designing effective risk assessments and therapeutic interventions to boost longevity and disease-free healthspan.
健康寿命是一种复杂的特征，受到许多加速或延缓衰老、降低或增加疾病风险、延长或缩短寿命的基因和环境因素的影响。因此，评估遗传变异在衰老中的作用需要一种能够模拟人类群体遗传和生物学复杂性的实验策略。杰克逊实验室内森·休克中心（JAX NSC）的目标是为老年科学研究人员提供研究资源和培训，这些研究人员试图通过实验室小鼠作为模型系统来了解遗传和遗传多样性对衰老基本过程以及人类衰老相关疾病的作用。JAX NSC 拥有新型、特征深度明确的老年小鼠群体，对与年龄相关的特征进行最先进的表型分析，对复杂数据集进行系统遗传学分析，并向老年科学社区提供所有这些资源。通过 JAX NSC 提供的老年动物资源、表型能力和遗传专业知识，通过促进否则不可能进行的前沿、新颖的研究线，使老年科学社区受益。在过去的 15 年中，JAX NSC 改变了整个老年科学社区的衰老研究，为研究人员提供了衰老小鼠资源和组织。所有 JAX NSC 数据和工具都在 Mouse Phenome Database 和 JAX NSC 网站上公开传播，从而确保通过该中心生成的资源和获得的专业知识可供衰老研究社区使用。JAX NSC 将继续增强其使用哺乳动物模型进行创新研究的能力，以阐明新的基因型-表型关系，并为设计有效的风险评估和治疗干预措施提供合理的依据，以延长寿命和无疾病的健康寿命。
