Wilson Rebekah L, Taaffe Dennis R, Newton Robert U, Hart Nicolas H, Lyons-Wall Philippa, Galvão Daniel A
Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Exercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, Australia.
Cancers (Basel). 2021 Jul 7;13(14):3411. doi: 10.3390/cancers13143411.
Supervised exercise and nutrition programs can mitigate or reverse androgen deprivation therapy (ADT) induced fat mass (FM) gain, lean mass (LM) loss, and impaired physical function. It is unclear whether these benefits are retained following transition to self-management. This study examined the effect of a home-based weight maintenance program on body composition and physical function in obese men with prostate cancer (PCa) on ADT following a 12-week supervised weight loss intervention. Eleven obese PCa patients (74 ± 5 years, 40.0 ± 4.9% body fat) on ADT (>6 months) completed a 12-week self-managed home-based weight maintenance program consisting of 150 min/week of aerobic and resistance training while maintaining a healthy balanced diet. Body composition (DXA), muscle strength (1RM), and cardiorespiratory fitness (400 m walk) were assessed. Significant reductions in weight (-2.8 ± 3.2 kg) and FM (-2.8 ± 2.6 kg), preservation of LM (-0.05 ± 1.6 kg), and improvements in muscle strength and VO were achieved across the supervised intervention. Across the home-based program, no significant changes were observed in weight (-0.6 ± 2.8 kg, = 0.508), FM (0.2 ± 1.4 kg, = 0.619), LM (-0.8 ± 1.6 kg, = 0.146), muscle strength (-0.2 to 4.1%, = 0.086-0.745), or estimated VO (0.3 ± 2.1 mL/min/kg, = 0.649). Self-managed, home-based exercise and nutrition programs are a viable strategy to promote maintenance of body composition and physical function following a supervised intervention in obese PCa patients on ADT.
有监督的运动和营养计划可以减轻或逆转雄激素剥夺治疗（ADT）引起的脂肪量（FM）增加、瘦体重（LM）减少和身体功能受损。目前尚不清楚在过渡到自我管理后这些益处是否能得以保留。本研究在一项为期12周的有监督减肥干预后，考察了一项居家体重维持计划对接受ADT治疗的肥胖前列腺癌（PCa）男性患者身体成分和身体功能的影响。11名接受ADT治疗（超过6个月）的肥胖PCa患者（74±5岁，体脂率40.0±4.9%）完成了一项为期12周的自我管理居家体重维持计划，该计划包括每周150分钟的有氧和抗阻训练，同时保持健康的均衡饮食。评估了身体成分（双能X线吸收法）、肌肉力量（1次重复最大值）和心肺适能（400米步行）。在有监督的干预期间，体重（-2.8±3.2千克）和FM（-2.8±2.6千克）显著降低，LM得以保留（-0.05±1.6千克），肌肉力量和摄氧量也有所改善。在居家计划期间，体重（-0.6±2.8千克，P=0.508）、FM（0.2±1.4千克，P=0.619）、LM（-0.8±1.6千克，P=0.146）、肌肉力量（-0.2%至4.1%，P=0.086至0.745）或估计摄氧量（0.3±2.1毫升/分钟/千克，P=0.649）均未观察到显著变化。对于接受ADT治疗的肥胖PCa患者，在有监督的干预之后，自我管理的居家运动和营养计划是促进维持身体成分和身体功能的可行策略。
