Farghadani Reyhaneh, Naidu Rakesh
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
Cancers (Basel). 2021 Jul 8;13(14):3427. doi: 10.3390/cancers13143427.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Despite the overall successes in breast cancer therapy, hormone-independent HER2 negative breast cancer, also known as triple negative breast cancer (TNBC), lacking estrogens and progesterone receptors and with an excessive expression of human epidermal growth factor receptor 2 (HER2), along with the hormone-independent HER2 positive subtype, still remain major challenges in breast cancer treatment. Due to their poor prognoses, aggressive phenotype, and highly metastasis features, new alternative therapies have become an urgent clinical need. One of the most noteworthy phytochemicals, curcumin, has attracted enormous attention as a promising drug candidate in breast cancer prevention and treatment due to its multi-targeting effect. Curcumin interrupts major stages of tumorigenesis including cell proliferation, survival, angiogenesis, and metastasis in hormone-independent breast cancer through the modulation of multiple signaling pathways. The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-ĸB pathway, p53 pathway, and Wnt/β-catenin, as well as apoptotic and cell cycle pathways. Besides, its therapeutic implications in clinical trials are here presented.
乳腺癌是全球女性中最常被诊断出的癌症，也是癌症死亡的主要原因。尽管乳腺癌治疗总体上取得了成功，但激素非依赖性HER2阴性乳腺癌，也称为三阴性乳腺癌（TNBC），缺乏雌激素和孕激素受体且人表皮生长因子受体2（HER2）过度表达，以及激素非依赖性HER2阳性亚型，仍然是乳腺癌治疗中的主要挑战。由于其预后不良、侵袭性表型和高转移特征，新的替代疗法已成为迫切的临床需求。最值得注意的植物化学物质之一姜黄素，因其多靶点作用，作为一种有前景的乳腺癌预防和治疗候选药物引起了广泛关注。姜黄素通过调节多种信号通路，干扰激素非依赖性乳腺癌肿瘤发生的主要阶段，包括细胞增殖、存活、血管生成和转移。本综述通过关注姜黄素对关键信号通路（包括PI3K/Akt/mTOR通路、JAK/STAT通路、MAPK通路、NF-κB通路、p53通路和Wnt/β-连环蛋白）以及凋亡和细胞周期通路的影响，突出了姜黄素在激素非依赖性乳腺癌中的抗癌活性。此外，还介绍了其在临床试验中的治疗意义。
