克服三阴性乳腺癌治疗中植物化学物质的挑战：前进之路。

Overcoming the Challenges of Phytochemicals in Triple Negative Breast Cancer Therapy: The Path Forward.

作者信息

Alaouna Mohammed, Penny Clement, Hull Rodney, Molefi Thulo, Chauke-Malinga Nkhensani, Khanyile Richard, Makgoka Malose, Bida Meshack, Dlamini Zodwa

机构信息

SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Pretoria 0001, South Africa.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.

出版信息

Plants (Basel). 2023 Jun 16;12(12):2350. doi: 10.3390/plants12122350.

DOI:10.3390/plants12122350

PMID:37375975

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10301029/

Abstract

Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway activation, which leads to cell invasion and metastasis. To address this, the use of phytochemicals as a therapeutic option for TNBC has been researched. Plants contain natural compounds known as phytochemicals. Curcumin, resveratrol, and EGCG are phytochemicals that have been found to inhibit the pathways that cause TNBC, but their limited bioavailability and lack of clinical evidence for their use as single therapies pose challenges to the use of these phytochemical therapies. More research is required to better understand the role of phytochemicals in TNBC therapy, or to advance the development of more effective delivery mechanisms for these phytochemicals to the site where they are required. This review will discuss the promise shown by phytochemicals as a treatment option for TNBC.

摘要

三阴性乳腺癌（TNBC）是一种侵袭性很强的乳腺癌亚型，缺乏雌激素、孕激素和HER2受体表达。TNBC被认为是由Wnt、Notch、TGF-β和VEGF通路激活产生的，这会导致细胞侵袭和转移。为了解决这个问题，人们对使用植物化学物质作为TNBC的治疗选择进行了研究。植物含有被称为植物化学物质的天然化合物。姜黄素、白藜芦醇和表没食子儿茶素没食子酸酯（EGCG）是已被发现能抑制导致TNBC的通路的植物化学物质，但它们有限的生物利用度以及缺乏作为单一疗法使用的临床证据，给这些植物化学物质疗法的应用带来了挑战。需要更多的研究来更好地理解植物化学物质在TNBC治疗中的作用，或者推进开发更有效的将这些植物化学物质输送到所需部位的机制。本综述将讨论植物化学物质作为TNBC治疗选择所展现出的前景。