Bellotti Ruben, Speth Cornelia, Adolph Timon E, Lass-Flörl Cornelia, Effenberger Maria, Öfner Dietmar, Maglione Manuel
Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Cancers (Basel). 2021 Jul 8;13(14):3431. doi: 10.3390/cancers13143431.
Dysbiosis of the intestinal flora has emerged as an oncogenic contributor in different malignancies. Recent findings suggest a crucial tumor-promoting role of micro- and mycobiome alterations also in the development of pancreatic ductal adenocarcinoma (PDAC).
To summarize the current knowledge about this topic, a systematic literature search of articles published until October 2020 was performed in MEDLINE (PubMed).
An increasing number of publications describe associations between bacterial and fungal species and PDAC development. Despite the high inter-individual variability of the commensal flora, some studies identify specific microbial signatures in PDAC patients, including oral commensals like and or Gram-negative bacteria like . The role of spp. remains unclear. Recent isolation of from PDAC tissue suggest also the mycobiota as a crucial player of tumorigenesis. Based on described molecular mechanisms and interactions between the pancreatic tissue and the immune system this review proposes a model of how the micro- and the mycobial dysbiosis could contribute to tumorigenesis in PDAC.
The presence of micro- and mycobial dysbiosis in pancreatic tumor tissue opens a fascinating perspective on PDAC oncogenesis. Further studies will pave the way for novel tumor markers and treatment strategies.
肠道菌群失调已成为不同恶性肿瘤的致癌因素。最近的研究结果表明，微生物群和真菌群的改变在胰腺导管腺癌（PDAC）的发展中也起着关键的促肿瘤作用。
为总结关于该主题的当前知识，于2020年10月在MEDLINE（PubMed）中对已发表的文章进行了系统的文献检索。
越来越多的出版物描述了细菌和真菌物种与PDAC发展之间的关联。尽管共生菌群存在高度个体差异，但一些研究在PDAC患者中确定了特定的微生物特征，包括如[具体菌种1]和[具体菌种2]等口腔共生菌或如[具体菌种3]等革兰氏阴性菌。[具体菌种4]的作用仍不清楚。最近从PDAC组织中分离出[具体菌种5]也表明真菌群是肿瘤发生的关键因素。基于所描述的胰腺组织与免疫系统之间的分子机制和相互作用，本综述提出了一个关于微生物群和真菌群失调如何促进PDAC肿瘤发生的模型。
胰腺肿瘤组织中微生物群和真菌群失调的存在为PDAC的肿瘤发生开辟了一个引人入胜的视角。进一步的研究将为新型肿瘤标志物和治疗策略铺平道路。
