Nencki Institute of Experimental Biology Polish Academy of Sciences, 02-093 Warsaw, Poland.
Faculty of Biology and Environmental Sciences, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland.
Int J Mol Sci. 2021 Jul 17;22(14):7664. doi: 10.3390/ijms22147664.
Shrews are small animals found in many different habitats. Like other mammals, adult neurogenesis occurs in the subventricular zone of the lateral ventricle (SVZ) and the dentate gyrus (DG) of the hippocampal formation. We asked whether the number of new generated cells in shrews depends on their brain size. We examined and , weighing 10-22 g, and and that weigh three times more. We found that the density of proliferated cells in the SVZ was approximately at the same level in all species. These cells migrated from the SVZ through the rostral migratory stream to the olfactory bulb (OB). In this pathway, a low level of neurogenesis occurred in compared to three other species of shrews. In the DG, the rate of adult neurogenesis was regulated differently. Specifically, the lowest density of newly generated neurons was observed in , which had a substantial number of new neurons in the OB compared with . We suggest that the number of newly generated neurons in an adult shrew's brain is independent of the brain size, and molecular mechanisms of neurogenesis appeared to be different in two neurogenic structures.
鼩鼱是一种生活在多种不同栖息地的小动物。与其他哺乳动物一样，成年神经发生发生在侧脑室（SVZ）的室下区和海马结构的齿状回（DG）。我们想知道在鼩鼱中，新产生的细胞数量是否取决于它们的大脑大小。我们检查了体重为 10-22 克的 和体重是它们三倍的 和 。我们发现，所有物种的 SVZ 中增殖细胞的密度大致相同。这些细胞从 SVZ 通过前脑侧脑室流出道迁移到嗅球（OB）。在这条途径中，与其他三种鼩鼱相比， 在成年神经发生中发生的水平较低。在 DG 中，成年神经发生的速度受到不同的调节。具体来说，在 中观察到新生成神经元的密度最低，而 与 相比，在 OB 中具有大量的新神经元。我们认为，成年鼩鼱大脑中新产生的神经元数量与大脑大小无关，并且两种神经发生结构中的神经发生分子机制似乎不同。
