Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Institute of Food Technology and Food Chemistry, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
Molecules. 2021 Jul 14;26(14):4275. doi: 10.3390/molecules26144275.
Sulfoquinovosyldiacylglycerol (SQDG) is a glycolipid ubiquitously found in photosynthetically active organisms. It has attracted much attention in recent years due to its biological activities. Similarly, the increasing demand for vegan and functional foods has led to a growing interest in micronutrients such as sulfolipids and their physiological influence on human health. To study this influence, reference materials are needed for developing new analytical methods and providing enough material for model studies on the biological activity. However, the availability of these materials is limited by the difficulty to isolate and purify sulfolipids from natural sources and the unavailability of chemical standards on the market. Consequently, an alternative synthetic route for the comprehensive preparation of sulfolipids was established. Here, the synthesis of a sulfolipid with two identical saturated fatty acids is described exemplarily. The method opens possibilities for the preparation of a diverse range of interesting derivatives with different saturated and unsaturated fatty acids.
磺基海藻糖二脂（SQDG）是一种在光合作用生物体中普遍存在的糖脂。由于其生物活性，近年来引起了广泛关注。同样，对素食和功能性食品的需求不断增加，也促使人们对诸如磺脂等微量营养素及其对人类健康的生理影响产生了浓厚的兴趣。为了研究这种影响，需要参考材料来开发新的分析方法，并为磺脂生物活性的模型研究提供足够的材料。然而，由于从天然来源中分离和纯化磺脂的难度以及市场上缺乏化学标准品，这些材料的可用性受到限制。因此，建立了一种综合制备磺脂的替代合成路线。这里，以合成两个相同饱和脂肪酸的磺脂为例进行了描述。该方法为制备具有不同饱和和不饱和脂肪酸的各种有趣衍生物开辟了可能性。
