Catalysis Laboratory, School of Chemistry, University of Hyderabad, Central University (P.O.), Gachibowli, Hyderabad 500 046, India.
Molecules. 2021 Jul 16;26(14):4320. doi: 10.3390/molecules26144320.
Biologically important, chiral natural products of butenolides, (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2, (+)-antimycinone, lipid metabolites, (+)-ancepsenolide, (+)-homoancepsenolide, mosquito larvicidal butenolide and their analogues were synthesized in very good yields in a sequential one-pot manner by using an organocatalytic reductive coupling and palladium-mediated reductive deoxygenation or organocatalytic reductive coupling and silica-mediated reductive deamination as the key steps.
生物活性手性天然产物丁烯内酯，(-)-blastmycinolactol、(+)-blastmycinone、(-)-NFX-2、(+)-antimycinone、脂类代谢物、(+)-ancepsenolide、(+)-homoancepsenolide、杀蚊幼虫丁烯内酯及其类似物，通过使用有机催化还原偶联和钯介导的还原脱氧或有机催化还原偶联和二氧化硅介导的还原脱氨作为关键步骤，以顺序一锅法在非常好的收率下合成。
