下颌骨棕色瘤继发甲状旁腺功能亢进症 1 例报告及文献复习并随访 5 年
Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism: A Case Report with 5 Years Follow-Up and Review of the Literature.
机构信息
Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
出版信息
Int J Environ Res Public Health. 2021 Jul 9;18(14):7370. doi: 10.3390/ijerph18147370.
BACKGROUND
Brown tumor is a rare skeletal manifestation of secondary hyperparathyroidism. Although diagnosis of the disease is increasingly seen in early stages due to improved screening techniques, some patients still present in a progressed disease stage. The treatment depends on tumor mass and varies from a conservative approach with supportive parathyroidectomy to extensive surgical resection with subsequent reconstruction.
CASE PRESENTATION
We report a case of extensive mandibular brown tumor in a patient with a history of systemic lupus erythematosus, chronic kidney disease, and secondary hyperparathyroidism. Following radical resection of the affected bone, reconstruction could be successfully performed using a free flap.
CONCLUSIONS
There were no signs of recurrence during five years of close follow-up. Increased awareness and multidisciplinary follow-ups could allow early diagnosis and prevent the need for radical therapeutical approaches.
背景
棕色瘤是继发甲状旁腺功能亢进症的一种罕见骨骼表现。尽管由于筛查技术的改进，该疾病的诊断在早期阶段越来越常见，但仍有一些患者处于进展期。治疗取决于肿瘤的大小，从支持性甲状旁腺切除术的保守治疗到广泛的手术切除和随后的重建。
病例介绍
我们报告了一例系统性红斑狼疮、慢性肾脏病和继发甲状旁腺功能亢进症病史患者的广泛下颌棕色瘤。受累骨广泛切除后，采用游离皮瓣成功进行了重建。
结论
在五年的密切随访中，没有复发迹象。提高认识和多学科随访可以早期诊断，并避免需要激进的治疗方法。
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