Movahhedian Najmeh, Khorrami Roya, Ghorbani Farhad, Zare Razieh
Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Corner of Mehr Ave., Qasrodasht St, Shiraz, Iran.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Oral Health. 2025 Jul 2;25(1):979. doi: 10.1186/s12903-025-06370-y.
Brown tumors are non-neoplastic giant cell lesions resulting from imbalanced bone metabolism associated with hyperparathyroidism. Although these tumors are infrequently found in the jaw bones, their presence can mimic other bony lesions, making differential diagnosis essential for effective treatment planning.
Here, we present a rare case of simultaneous involvement of both jaws by brown tumors in a 37-year-old woman. A comprehensive diagnostic approach including cone beam computed tomographic examination of the jaws, blood biochemistry, scintigraphy (technetium 99 m sestamibi), and biopsy facilitated the identification of underlying parathyroid carcinoma. Notably, the patient experienced spontaneous healing of the extensive brown tumors following endocrine treatment, underscoring the potential for recovery in such cases.
This case highlights the essential collaboration between dental and medical professionals in diagnosing complex systemic diseases with oral manifestations, underscoring the dentist's critical role in early detection and improved patient outcomes.
棕色瘤是由甲状旁腺功能亢进相关的骨代谢失衡导致的非肿瘤性巨细胞病变。尽管这些肿瘤在颌骨中很少见,但其存在可能会模仿其他骨病变,因此鉴别诊断对于有效的治疗计划至关重要。
在此,我们报告一例罕见的37岁女性双侧颌骨同时受累于棕色瘤的病例。包括颌骨锥形束计算机断层扫描检查、血液生化检查、闪烁扫描(锝99m甲氧基异丁基异腈)和活检在内的综合诊断方法有助于识别潜在的甲状旁腺癌。值得注意的是,患者在内分泌治疗后广泛的棕色瘤出现了自发愈合,突出了此类病例的恢复潜力。
本病例强调了牙科和医学专业人员在诊断有口腔表现的复杂全身性疾病时的必要协作,突出了牙医在早期检测和改善患者预后方面的关键作用。