Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Trigoria, 00128 Rome, Italy.
Orthopaedic Surgery Department, Hospital Universitario Puerta de Hierro, Majadahonda, 28222 Madrid, Spain.
Int J Environ Res Public Health. 2021 Jul 13;18(14):7471. doi: 10.3390/ijerph18147471.
Osteoarthritis (OA) of the glenohumeral (GH) joint is a common cause of shoulder pain, resulting in considerable invalidity. Unfortunately, the study of its pathogenesis is challenging. Models of OA are necessary to identify specific targets for therapy and to be able to interfere with the development and evolution of OA. This study aims to assess the effect of an arthroscopic tenotomy of the long head of the biceps tendon (LHBT) and section of the anterior glenohumeral joint capsule on the ovine glenohumeral joint. In addition, the authors aim to validate and evaluate the reliability of a modified semi-quantitative MRI score to assess joint degeneration in a sheep's shoulder. Eight skeletally mature sheep received an arthroscopic tenotomy of the LHBT and section of the anterior joint capsule and were euthanized four months after surgery. All animals tolerated the surgery well, and no complication was recorded for six weeks. Moderate degenerative changes to the ovine shoulder joint were found on MRI and histological evaluation. The arthroscopic tenotomy of the LHBT and the anterior glenohumeral joint capsule section caused moderate degenerative changes to the ovine shoulder joint.
肩盂肱关节（GH）骨关节炎（OA）是引起肩部疼痛的常见原因，导致相当大的残疾。不幸的是，其发病机制的研究具有挑战性。OA 模型对于确定治疗的特定靶点以及能够干预 OA 的发展和演变是必要的。本研究旨在评估关节镜下肱二头肌长头肌腱（LHBT）切断术和前盂肱关节囊切开术对羊 GH 关节的影响。此外，作者旨在验证和评估改良的半定量 MRI 评分来评估绵羊肩部关节退变的可靠性。8 只骨骼成熟的绵羊接受了关节镜下 LHBT 切断术和前关节囊切开术，并在手术后四个月安乐死。所有动物均能很好地耐受手术，并且在六周内未记录到任何并发症。MRI 和组织学评估发现绵羊肩关节有中度退行性改变。LHBT 的关节镜下切断术和前盂肱关节囊切开术导致绵羊肩关节有中度退行性改变。
