Longo Umile Giuseppe, Papalia Rocco, De Salvatore Sergio, Picozzi Riccardo, Sarubbi Antonio, Denaro Vincenzo
Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy.
Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy.
Biology (Basel). 2023 Feb 10;12(2):283. doi: 10.3390/biology12020283.
The most common induction methods for OA are mechanical, surgical and chemical. However, there is not a gold standard in the choice of OA animal models, as different animals and induction methods are helpful in different contexts. Reporting the latest evidence and results in the literature could help researchers worldwide to define the most appropriate indication for OA animal-model development. This review aims to better define the most appropriate animal model for various OA conditions. The research was conducted on the following literature databases: Medline, Embase, Cinahl, Scopus, Web of Science and Google Scholar. Studies reporting cases of OA in animal models and their induction from January 2010 to July 2021 were included in the study and reviewed by two authors. The literature search retrieved 1621 articles, of which 36 met the selection criteria and were included in this review. The selected studies included 1472 animals. Of all the studies selected, 8 included information about the chemical induction of OA, 19 were focused on mechanical induction, and 9 on surgical induction. Nevertheless, it is noteworthy that several induction models, mechanical, surgical and chemical, have been proven suitable for the induction of OA in animals.
骨关节炎（OA）最常见的诱导方法有机械法、手术法和化学法。然而，在OA动物模型的选择上并没有金标准，因为不同的动物和诱导方法在不同的情况下都有帮助。报道文献中的最新证据和结果有助于全球的研究人员确定OA动物模型开发的最合适指征。本综述旨在更好地确定适用于各种OA情况的最合适动物模型。研究在以下文献数据库中进行：医学文献数据库（Medline）、荷兰医学文摘数据库（Embase）、护理学与健康领域数据库（Cinahl）、Scopus数据库、科学引文索引数据库（Web of Science）和谷歌学术。纳入研究的是2010年1月至2021年7月期间报道动物模型中OA病例及其诱导情况的研究，并由两位作者进行综述。文献检索共获得1621篇文章，其中36篇符合入选标准并被纳入本综述。所选研究共涉及1472只动物。在所有入选研究中，8篇包含有关OA化学诱导的信息，19篇侧重于机械诱导，9篇侧重于手术诱导。然而，值得注意的是，几种诱导模型，包括机械、手术和化学模型，已被证明适用于在动物中诱导OA。
