Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Clinical Laboratory, The University of Tokyo, Tokyo, Japan.
J Med Ultrason (2001). 2022 Jan;49(1):53-60. doi: 10.1007/s10396-021-01115-0. Epub 2021 Jul 23.
Advanced age is widely recognized as a key risk factor for incident cardiovascular disease. The age-associated changes in cardiac properties alter the substrate on which cardiovascular disease is superimposed in various ways, and thus affect the development and manifestations of cardiovascular disease (CVD) in the elderly. However, it is still unclear whether age-related cardiac alteration is attributed to aging itself or whether it is secondary to other acquired cardiovascular risk factors. Understanding the association between aging and cardiac functional remodeling might provide insight into the pathogenesis of cardiovascular aging and may help inform possible preventive strategies for CVD in older individuals. Speckle-tracking echocardiography enables the objective and quantitative assessment of subtle myocardial alterations that are undetectable with conventional echocardiography, and has excellent feasibility and reproducibility. Left ventricular (LV) global longitudinal strain, a sensitive measure of LV systolic dysfunction, was found to be an independent risk factor for cardiovascular morbidity and mortality. More recently, deformation imaging has been employed to assess right ventricular (RV) and atrial performance, and impaired RV and atrial strain predict unfavorable outcomes in various clinical settings. This article reviews the association between aging and changes in myocardial strain values and describes future perspectives.
高龄是公认的心血管疾病的重要危险因素。心脏特性随年龄的变化以多种方式改变了心血管疾病叠加的基础，从而影响老年人心血管疾病（CVD）的发展和表现。然而，目前仍不清楚与年龄相关的心脏改变是归因于衰老本身，还是继发于其他获得性心血管危险因素。了解衰老与心脏功能重塑之间的关联可能有助于深入了解心血管衰老的发病机制，并可能为老年个体的 CVD 提供可能的预防策略。斑点追踪超声心动图能够客观、定量地评估常规超声心动图无法检测到的细微心肌改变，具有良好的可行性和可重复性。左心室（LV）整体纵向应变是一种敏感的 LV 收缩功能障碍测量指标，被发现是心血管发病率和死亡率的独立危险因素。最近，变形成像已被用于评估右心室（RV）和心房功能，RV 和心房应变受损预测各种临床情况下的不良结局。本文综述了衰老与心肌应变值变化之间的关系，并描述了未来的展望。
