巴黎旋覆花地上部分中的蜕皮甾酮。

Ecdysteroids from the Aerial Parts of Paris verticillata.

机构信息

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, P. R. China.

出版信息

Chem Biodivers. 2021 Sep;18(9):e2100239. doi: 10.1002/cbdv.202100239. Epub 2021 Aug 9.

DOI:10.1002/cbdv.202100239

PMID:34302431

Abstract

Two new ecdysteroids 14-epi-polypodine B (1) and 22-oxo-hydroxyecdysterone (2), along with nine known compounds, polypodine B (3), viticosterone E (4), 20-hdroxyecdysone-2-acetate (5), 22-oxo-20-hydroxyecdysone (6), 5-hydroxyecdysone (7), pinnatasterone (8), 3-epi-20-hydroxyecdysone (9), ecdysterone (10) and stachysterone B (11), were isolated from the aerial parts of Paris verticillata. The structures of all compounds were elucidated by extensive spectroscopic analysis, quantum chemical calculations and ANN-PRA/DP4 probability analysis. Among them, the absolute configuration of compound 1 and 2 was unambiguous determined by ECD. Also, the isolated compounds were assessed for their cytotoxic activities. Compounds 2, 3 and 7 exhibited significant cytotoxic activities against PC12, LN299 and SMCC7721 cells.

摘要

从短梗霉科植物垂序商陆的地上部分分离得到两种新的蜕皮甾酮 14-表-多刺槐定 B（1）和 22-氧代-羟基蜕皮甾酮（2），以及 9 种已知化合物：多刺槐定 B（3）、表育亨宾 E（4）、20-羟基蜕皮甾酮-2-乙酸酯（5）、22-氧代-20-羟基蜕皮甾酮（6）、5-羟基蜕皮甾酮（7）、平那甾酮（8）、3-表-20-羟基蜕皮甾酮（9）、蜕皮甾酮（10）和白首乌苷 B（11）。通过广泛的光谱分析、量子化学计算和 ANN-PRA/DP4 概率分析确定了所有化合物的结构。其中，化合物 1 和 2 的绝对构型通过 ECD 明确确定。此外，还评估了分离得到的化合物对 PC12、LN299 和 SMCC7721 细胞的细胞毒性活性。化合物 2、3 和 7 对 PC12、LN299 和 SMCC7721 细胞表现出显著的细胞毒性活性。