McLoughlin L C, Nord K S, Joshi V V, Oleske J M, Connor E M
Department of Pediatrics, Children's Hospital of New Jersey, UMDNJ-New Jersey Medical School, Newark 07107.
J Pediatr Gastroenterol Nutr. 1987 Jul-Aug;6(4):517-24. doi: 10.1097/00005176-198707000-00004.
Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. Jejunal biopsy from the second child revealed infiltration of the mucosa with acid-fast bacilli-laden macrophages. A third child suffered recurrent abdominal pain, progressive weight loss, diarrhea, and severe gastrointestinal hemorrhage secondary to infection with cytomegalovirus. Pseudomembranous necrotizing jejunitis associated with overgrowth of Klebsiella pneumoniae in the duodenal fluid occurred in one patient. The fifth child presented in the newborn period with Serratia marcescens cholecystitis. Gastrointestinal disease in children with AIDS may be due to idiopathic villus atrophy and bacterial or opportunistic infection.
本文描述了五名患有获得性免疫缺陷综合征（艾滋病）及特殊胃肠道疾病的儿童。两名儿童表现为营养不良、腹胀和腹泻。其中一名儿童经空肠活检发现有中度严重的绒毛萎缩，最初被认为患有乳糜泻。第二名儿童的空肠活检显示黏膜中有含抗酸杆菌的巨噬细胞浸润。第三名儿童因巨细胞病毒感染继发反复腹痛、进行性体重减轻、腹泻和严重胃肠道出血。一名患者发生了与十二指肠液中肺炎克雷伯菌过度生长相关的假膜性坏死性空肠炎。第五名儿童在新生儿期出现粘质沙雷氏菌胆囊炎。艾滋病患儿的胃肠道疾病可能是由于特发性绒毛萎缩以及细菌或机会性感染所致。
