Quesnel A, Moja P, Blanche S, Griscelli C, Genin C
Laboratory of Research in Immunology, University of Saint-Etienne, France.
Clin Exp Immunol. 1994 Sep;97(3):380-5. doi: 10.1111/j.1365-2249.1994.tb06098.x.
This study was performed in 27 HIV-1+ children to characterize the IgA hyperglobulinaemia observed in the serum during the course of HIV-1 infection. By contrast with serum IgG, which increased very early, IgA elevation was related to the decrease of CD4+ cell percentage. It was demonstrated that IgA1 subclass increased selectively. Secretory IgA (SIgA) and IgA and IgG activity to gliadin, bovine serum albumin (BSA) and at a lower level to casein could be detected in the serum at the early stages of HIV infection, but SIgA levels and IgA activity to gliadin further increased during the course of immunodeficiency. By contrast, IgA and IgG activity to tetanus toxoid did not change. These data demonstrate that the hyper IgA, closely related to the degree of immunodeficiency, could be due in part to a disturbance of the gut mucosal immune system. Moreover, impaired intestinal immunity seems to appear very early, and to progress during the course of paediatric HIV-1 infection.
本研究对27名HIV-1阳性儿童进行，以表征在HIV-1感染过程中血清中观察到的IgA高球蛋白血症。与早期就升高的血清IgG相反，IgA升高与CD4+细胞百分比降低有关。已证明IgA1亚类选择性增加。在HIV感染早期，血清中可检测到分泌型IgA（SIgA）以及IgA和IgG对麦醇溶蛋白、牛血清白蛋白（BSA）的活性，对酪蛋白的活性较低，但在免疫缺陷过程中，SIgA水平和IgA对麦醇溶蛋白的活性进一步升高。相比之下，IgA和IgG对破伤风类毒素的活性没有变化。这些数据表明，与免疫缺陷程度密切相关的高IgA可能部分归因于肠道黏膜免疫系统的紊乱。此外，肠道免疫受损似乎很早就出现，并在儿童HIV-1感染过程中进展。
