OncoWitan, Lille (Wasquehal), 59290, France.
J Ethnopharmacol. 2021 Nov 15;280:114444. doi: 10.1016/j.jep.2021.114444. Epub 2021 Jul 21.
Extracts of the plant Selaginella tamariscina (P.Beauv.) Spring (spike moss) are used for a long time in Asia, for the treatment of multiple diseases and conditions. Aqueous and alcoholic leave extracts are used by local communities. In China, the plant (Juan bai) is listed on the Pharmacopoeia. In South Korea, the use of this plant (Kwon Baek) is mentioned in the book Dongui-Bogam (Heo Jun 1613), at the origin of the Hyungsang medicine. S. tamariscina is traditionally used in Vietnam (mong lung rong), Thailand (dok hin), Philippines (pakong-tulog) and other Asian countries.
To provide an analysis of the multiple traditional and current uses of S. tamariscina extracts (STE) in the field of medicine and cosmetic. The review is also intended at identifying the main natural products at the origin of the many pharmacological properties reported with these extracts (anti-inflammatory, antioxidant, antidiabetic, antibacterial, antiallergic, anticancer effects).
Extensive database retrieval, such as SciFinder and PubMed, was performed by using keywords like " Selaginella tamariscina", "spike moss", "Selaginellaceae ". Relevant textbooks, patents, reviews, and digital documents were consulted to collate all available scientific literature and to provide a complete science-based survey of the topic.
Different solvents and methods are used to prepare STE. The process can largely modify the natural product content and properties of the extracts. STE display a range of pharmacological effects, useful to treat metabolic disorders, several inflammatory diseases and various cancers. A specific carbonized extract (S. tamariscina carbonisatus) has shown hemostatic effects, whereas standard STE can promote blood circulation. Many patented STE-containing cosmetic preparations are reviewed here. Several biflavonoids (chiefly amentoflavone) and phenolic compounds (selaginellin derivatives) are primarily responsible for the observed pharmacological properties. Potent inhibitors of protein tyrosine phosphatase 1 B (PTP1B), phosphodiesterase-4 (PDE4), and repressor of pro-inflammatory cytokines expression have been identified from STE.
The traditional use of STE supports the research performed with this plant. There are robust experimental data, based on in vitro and in vivo models, documenting the use of STE to treat type 2 diabetes, several inflammatory diseases, and some cancers (in combination with standard chemotherapy). Selaginella tamariscina (P.Beauv.) is a prime reservoir for amentoflavone, and many other bioactive natural products. The interest of the plant in medicine and cosmetic is amply justified.
植物卷柏（P.Beauv.）的提取物（刺柏）在亚洲被长期用于治疗多种疾病和病症。当地社区使用水提物和醇提物。在中国，该植物（卷柏）被列入药典。在韩国，该植物（苦参）在《东医宝鉴》（Heo Jun 1613 年）一书中有记载，这是 Hyungsang 医学的起源。卷柏在越南（mong lung rong）、泰国（dok hin）、菲律宾（pakong-tulog）和其他亚洲国家被传统使用。
分析卷柏提取物（STE）在医学和美容领域的多种传统和当前用途。综述还旨在确定许多报道的 STE 具有的多种药理作用的主要天然产物（抗炎、抗氧化、抗糖尿病、抗菌、抗变态反应、抗癌作用）。
通过使用“卷柏”、“刺柏”、“卷柏科”等关键词，在 SciFinder 和 PubMed 等广泛的数据库中进行了检索。查阅了相关教科书、专利、综述和数字文献，以整理所有可用的科学文献，并对该主题进行全面的科学调查。
不同的溶剂和方法用于制备 STE。该过程可以极大地改变提取物的天然产物含量和性质。STE 显示出一系列药理作用，可用于治疗代谢紊乱、多种炎症性疾病和各种癌症。一种特殊的碳化提取物（卷柏炭）已显示出止血作用，而标准 STE 可促进血液循环。本文综述了几种含有 STE 的专利化妆品制剂。几种双黄酮（主要是芹菜甲素）和酚类化合物（卷柏素衍生物）是观察到的药理作用的主要原因。从 STE 中鉴定出蛋白酪氨酸磷酸酶 1B（PTP1B）、磷酸二酯酶-4（PDE4）和炎症细胞因子表达抑制剂的有效抑制剂。
STE 的传统用途支持对该植物进行的研究。基于体外和体内模型的大量实验数据记录了使用 STE 治疗 2 型糖尿病、多种炎症性疾病和某些癌症（与标准化疗联合使用）。卷柏（P.Beauv.）是芹菜甲素和许多其他生物活性天然产物的主要来源。该植物在医学和美容领域的应用是有充分理由的。
