Department of Obstetrics &Gynaecology, Clinical Director, Mpilo Central Hospital, Vera Road, Mzilikazi, Zimbabwe; Royal Women's Clinic, 52A Cecil Avenue, Hillside, Zimbabwe; National University of Science and Technology, Medical School, Bulawayo, Matabeleland, Zimbabwe.
National University of Science & Technology, P. O. Box AC 939, Ascot, Bulawayo, Matabeleland, Zimbabwe.
Pregnancy Hypertens. 2021 Aug;25:235-239. doi: 10.1016/j.preghy.2021.07.240. Epub 2021 Jul 20.
Globally, preeclampsia is a significant contributor to adverse maternal outcomes. Once women develop eclampsia, they face considerable risks especially in countries with limited resources to deal with such a life-threatening complication. This study was carried out to investigate determinants of eclampsia in pregnant mothers with severe preeclampsia.
This institutional based study was completed at Mpilo Central Hospital, a quaternary referral unit from 1st January 2016 - 31st December 2018. In this study, pregnant women with severe preeclampsia/eclampsia were the study participants. The independent variables included socio-demographic and clinical characteristics, and maternal outcomes. Multivariable logistic regression analyses were used to determine independent association with p < 0.05 taken as statistically significant with 95% Confidence Interval (CI).
Eclampsia.
Development of eclampsia was more frequent in women aged 14-19 years compared to women aged ≥ 35 years (adjusted odds ratio (AOR) 6.64, 95% CI 1.20-22.06, p = 0.02) and in primiparous women compared to women with parity ≥ 3 (AOR 2.76, 95% CI 1.48-5.15, p = 0.001). Eclampsia was more frequent in women with diastolic blood pressure of 131-150 mmHg (AOR 5.48, 95% CI 1.05-28.75, p = 0.04), and ≥ 150 mmHg (AOR 5.78, 95% CI 1.05-31.78, p = 0.04) compared with those with diastolic blood pressure of ≤ 110 mmHg. Symptoms of visual disturbances were also associated with eclampsia (AOR 2.13, 95% CI 1.08-4.18, p = 0.03).
This study has identified independent determinants of eclampsia which can be used to identify which women should receive magnesium sulphate prophlyaxis or more intensive monitoring to prevent deterioration in maternal condition.
在全球范围内，子痫前期是导致不良母婴结局的一个重要因素。一旦女性发展为子痫，她们将面临巨大的风险，尤其是在资源有限的国家，难以应对这种危及生命的并发症。本研究旨在探讨重度子痫前期孕妇子痫的发病决定因素。
这项基于机构的研究于 2016 年 1 月 1 日至 2018 年 12 月 31 日在姆皮洛中央医院进行，该医院是一个四级转诊单位。在这项研究中，患有重度子痫前期/子痫的孕妇为研究对象。自变量包括社会人口学和临床特征以及母婴结局。多变量逻辑回归分析用于确定与 p < 0.05 有统计学意义的独立关联，95%置信区间（CI）。
子痫。
与年龄≥35 岁的女性相比，14-19 岁的女性发生子痫的频率更高（调整后的优势比（AOR）6.64，95%CI 1.20-22.06，p=0.02），与经产妇相比，初产妇发生子痫的频率更高（AOR 2.76，95%CI 1.48-5.15，p=0.001）。与舒张压≤110mmHg 的女性相比，舒张压为 131-150mmHg（AOR 5.48，95%CI 1.05-28.75，p=0.04）和≥150mmHg 的女性发生子痫的频率更高（AOR 5.78，95%CI 1.05-31.78，p=0.04）。视觉障碍症状也与子痫有关（AOR 2.13，95%CI 1.08-4.18，p=0.03）。
本研究确定了子痫的独立决定因素，可用于识别哪些女性应接受硫酸镁预防或更密切监测，以防止母婴病情恶化。
