From the Department of Pathology, University of Michigan Medical School, Ann Arbor (Drs Weindorf, Brown, McHugh, and Udager).
the University of Michigan Rogel Cancer Center, Ann Arbor (Dr Udager).
Arch Pathol Lab Med. 2019 Nov;143(11):1304-1316. doi: 10.5858/arpa.2019-0372-RA.
CONTEXT.—: Sinonasal papillomas and carcinomas are uncommon head and neck neoplasms that comprise a broad clinicopathologic and morphologic spectrum, and thus frequently represent a diagnostic challenge for surgical pathologists. Recent molecular interrogation of these tumors has delineated a number of recurrent alterations that correspond to distinct entities with potential diagnostic and/or therapeutic clinical utility.
OBJECTIVE.—: To summarize the salient clinicopathologic, morphologic, and molecular features of sinonasal papillomas and carcinomas.
DATA SOURCES.—: Review of pertinent literature regarding sinonasal papillomas and sinonasal carcinomas.
CONCLUSIONS.—: Despite their relative rarity in many surgical pathology practices, sinonasal papillomas and carcinomas frequently demonstrate characteristic morphologic features that are important for accurate diagnosis. Given our emerging understanding of the molecular basis for these tumors, judicious use of available ancillary tools-including immunohistochemistry and in situ hybridization-may be helpful in subsets of cases, whereas additional molecular testing may be useful for diagnostically challenging and/or clinically aggressive sinonasal tumors.
鼻腔鼻窦乳头状瘤和癌是一种不常见的头颈部肿瘤，具有广泛的临床病理和形态学特征，因此经常对外科病理学家构成诊断挑战。最近对这些肿瘤的分子检测已经确定了许多反复出现的改变，这些改变与具有潜在诊断和/或治疗临床应用价值的不同实体相对应。
总结鼻腔鼻窦乳头状瘤和癌的显著临床病理、形态学和分子特征。
对有关鼻腔鼻窦乳头状瘤和鼻腔鼻窦癌的相关文献进行了回顾。
尽管在许多外科病理实践中相对少见，但鼻腔鼻窦乳头状瘤和癌通常表现出对准确诊断很重要的特征性形态特征。鉴于我们对这些肿瘤分子基础的认识不断加深，明智地使用现有的辅助工具，包括免疫组织化学和原位杂交，在某些情况下可能会有所帮助，而对于诊断具有挑战性和/或临床侵袭性的鼻腔鼻窦肿瘤，可能需要进一步的分子检测。
