Lilja Markus, Viitasalo Sanna, Hytönen Maija, Haapaniemi Aaro, Hagström Jaana, Mäkitie Antti
Department of Otorhinolaryngology-Head and Neck Surgery University of Helsinki and HUS Helsinki University Hospital Helsinki Finland.
Department of Pathology, Haartman Institute University of Helsinki Helsinki Finland.
Laryngoscope Investig Otolaryngol. 2019 Sep 30;4(6):567-572. doi: 10.1002/lio2.308. eCollection 2019 Dec.
Reports on sinonasal oncocytic papilloma (SNOP) are scarce. The aim of this retrospective study was to evaluate the clinical features of this rarest form of sinonasal papilloma with special emphasis on the pattern of recurrences and on the potential factors predicting them.
Retrospective study.
Between the years 1994 and 2016, 20 patients (mean age 66 years; range 30-87) were diagnosed with SNOP at the Department of Otorhinolaryngology-Head and Neck Surgery, HUS Helsinki University Hospital (Helsinki, Finland). Hospital charts were reviewed to record various medical and sociodemographic patient characteristics, and the archived histological specimens were re-evaluated. Postoperative follow-up time varied between 26 days and 167 months.
Maxillary sinus was the most common (60%) tumor location. None of the tissue samples showed dysplasia. Recurrence rate was 39% and the median time span to the first recurrence was 25 months (range 7-71). Smokers had more often a recurrence than nonsmokers (75% vs. 31%). Patients with perioperative purulent rhinosinusitis during the primary surgery had a higher recurrence rate compared with those without (60% vs. 31%). Tumors located in the sinuses recurred more often than those located in the nasal cavity (45% vs. 29%). However, all these findings remained statistically nonsignificant. None of the cases showed malignant transformation during the follow-up.
SNOP has a propensity to recur. History of smoking, purulent rhinosinusitis during the primary surgery, and tumor location in the sinuses outside the nasal cavity seem to contribute to an increased trend in the risk of recurrence.
关于鼻窦嗜酸性细胞乳头状瘤（SNOP）的报道较少。本回顾性研究的目的是评估这种最罕见的鼻窦乳头状瘤的临床特征，特别强调复发模式以及预测复发的潜在因素。
回顾性研究。
1994年至2016年间，20例患者（平均年龄66岁；范围30 - 87岁）在芬兰赫尔辛基大学医院耳鼻喉头颈外科被诊断为SNOP。回顾医院病历以记录患者的各种医学和社会人口统计学特征，并对存档的组织学标本进行重新评估。术后随访时间在26天至167个月之间。
上颌窦是最常见的肿瘤部位（60%）。所有组织样本均未显示发育异常。复发率为39%，首次复发的中位时间为25个月（范围7 - 71个月）。吸烟者比不吸烟者更常复发（75%对31%）。初次手术期间有围手术期化脓性鼻窦炎的患者与无此情况的患者相比，复发率更高（60%对31%）。位于鼻窦的肿瘤比位于鼻腔的肿瘤更常复发（45%对29%）。然而，所有这些发现仍无统计学意义。随访期间无一例发生恶变。
SNOP有复发倾向。吸烟史、初次手术期间的化脓性鼻窦炎以及鼻腔外鼻窦的肿瘤位置似乎会增加复发风险趋势。
4级。
